Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships

• Main Authors: Sonthaya Umsumarng, Pornsiri Pitchakarn, Supachai Yodkeeree, Wanisa Punfa, Sariya Mapoung, Rosdayati Alino Ramli, Stephen G. Pyne, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028725461&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56684
• Institution: Chiang Mai University

© 2017 Elsevier GmbH Background Multidrug resistance (MDR) is a major reason for the failure of chemotherapy in the treatment of cancer patients. P-gp over-expression in MDR cancer cells is a multifactorial phenomenon with biochemical resistance mechanisms. Stemofoline (STF), isolated from Stemona b...