CXCR4 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition

• Main Authors: Chuda Chittasupho, Songyot Anuchapreeda, Narong Sarisuta
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85023190732&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56703
• Institution: Chiang Mai University

© 2017 Elsevier B.V. CXCR4 and its ligand CXCL12 play a critical role in the metastasis of various types of cancer including breast cancer. Breast tumors preferentially metastasize to the lung, bones and distant lymph nodes, secreting high levels of CXCL12. We hypothesized that targeted inhibition o...