Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense

• Main Authors: Kattareeya Kumthip, Darong Yang, Nan L. Li, Yunzhi Zhang, Meiyun Fan, Aarti Sethuraman, Kui Li
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033217819&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56705
• Institution: Chiang Mai University

© 2017 Kumthip et al. The activation of interferon (IFN)-regulatory factor-3 (IRF3), characterized by phosphorylation and nuclear translocation of the latent transcription factor, is central to initiating innate antiviral responses. Whereas much has been learned about the upstream pathways and signa...