A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

© 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhi...

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Main Authors:	Tadayoshi Onozawa, Mariko Kitajima, Noriyuki Kogure, Nichakan Peerakam, Dammrong Santiarworn, Hiromitsu Takayama
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56730
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-56730
record_format	dspace
spelling	th-cmuir.6653943832-567302018-09-05T03:51:41Z A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics © 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis. 2018-09-05T03:29:31Z 2018-09-05T03:29:31Z 2017-07-28 Journal 15206025 01633864 2-s2.0-85026509664 10.1021/acs.jnatprod.7b00290 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56730
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
description	© 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis.
format	Journal
author	Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama
author_facet	Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama
author_sort	Tadayoshi Onozawa
title	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_short	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_fullStr	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full_unstemmed	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_sort	cyclopeptide and a tetrahydroisoquinoline alkaloid from ophiorrhiza nutans
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56730
_version_	1681424746731798528

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

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