Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

© 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectrosco...

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Main Authors:	Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56829
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-568292018-09-05T03:52:07Z Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics © 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC50value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC50values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively. 2018-09-05T03:30:48Z 2018-09-05T03:30:48Z 2017-01-01 Journal 18733581 00404039 2-s2.0-85015307707 10.1016/j.tetlet.2017.03.020 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56829
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
description	© 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC50value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC50values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively.
format	Journal
author	Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan
author_facet	Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan
author_sort	Sirada Boonyaketgoson
title	Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_short	Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full	Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_fullStr	Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full_unstemmed	Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_sort	cytotoxic arylbenzofuran and stilbene derivatives from the twigs of artocarpus heterophyllus
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56829
_version_	1681424765143744512

Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

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