Flow-injection determination of cinnarizine using surfactant-enhanced permanganate chemiluminesence
Chemiluminescence (CL) of permanganate system in the presence of polyphosphoric acid (PPA), ethanol and Tween 60 was investigated and implemented using flow-injection analysis (FIA) to determine cinnarizine (C) in pharmaceutical preparations. Five hundred microliter samples were injected and the sam...
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| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0345171512&partnerID=40&md5=1202446202bf0ee2258138c1c200f46f http://cmuir.cmu.ac.th/handle/6653943832/5684 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | Chemiluminescence (CL) of permanganate system in the presence of polyphosphoric acid (PPA), ethanol and Tween 60 was investigated and implemented using flow-injection analysis (FIA) to determine cinnarizine (C) in pharmaceutical preparations. Five hundred microliter samples were injected and the sample throughput was 130h-1. Preliminary experiments identified Tween 60 as the surfactant of choice, improving the detection limit of the CL system 20-fold. Optimum CL signals were given using 7.5×10 -4moll-1 potassium permanganate in 0.02moll-1 polyphospheous 1.5×10-3moll-1 Tween oric acid as the oxidant stream and a carrier stream of 10% (v/v) of ethanol in aqu60 with a total flow rate of 7.6mlmin-1. The calibration graph was linear over the range 0.5-6.0μgml-1 (r=0.9963, n=7). The detection limit (3σ) was 18ngml-1 and the percentage recovery of spiked tablet solutions was 98.4-100.2. © 2003 Elsevier B.V. All rights reserved. |
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