Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf>
© 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation...
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th-cmuir.6653943832-569722018-09-05T03:32:51Z Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> Wong Phakhodee Sirilak Wangngae Mookda Pattarawarapan Chemistry © 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions. 2018-09-05T03:32:51Z 2018-09-05T03:32:51Z 2017-08-04 Journal 15206904 00223263 2-s2.0-85027057783 10.1021/acs.joc.7b01322 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56972 |
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Chemistry |
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Chemistry Wong Phakhodee Sirilak Wangngae Mookda Pattarawarapan Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| description |
© 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions. |
| format |
Journal |
| author |
Wong Phakhodee Sirilak Wangngae Mookda Pattarawarapan |
| author_facet |
Wong Phakhodee Sirilak Wangngae Mookda Pattarawarapan |
| author_sort |
Wong Phakhodee |
| title |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_short |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_full |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_fullStr |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_full_unstemmed |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_sort |
approach to the synthesis of 2,3-disubstituted-3h-quinazolin-4-ones mediated by ph<inf>3</inf>p-i<inf>2</inf> |
| publishDate |
2018 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56972 |
| _version_ |
1681424791897112576 |