Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency

© 2016, Springer Science+Business Media Dordrecht. Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still uncl...

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Main Authors: Sakorn Pornprasert, Phenphichar Wanachantararak, Fahsai Kantawong, Supoj Chamnanprai, Chatpat Kongpan, Nattasit Pienthai, Jintana Yanola, Suwit Duangmano, Mujalin Prasannarong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57203
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-572032018-09-05T03:40:15Z Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency Sakorn Pornprasert Phenphichar Wanachantararak Fahsai Kantawong Supoj Chamnanprai Chatpat Kongpan Nattasit Pienthai Jintana Yanola Suwit Duangmano Mujalin Prasannarong Earth and Planetary Sciences Environmental Science © 2016, Springer Science+Business Media Dordrecht. Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still unclear. The fluoride in serum and urine and haematological parameters of students at Mae Tuen School (fluoride endemic area) were analysed and compared to those of students at Baan Yang Poa and Baan Mai Schools (control areas). Iron deficiency, thalassaemia, and G-6-PD deficiency were also diagnosed in these students. The students at Mae Tuen School had significantly (P < 0.001) higher levels of mean fluoride in the serum and urine than those in control areas. In both control and fluoride endemic areas, students with haematological disorders had significantly lower levels of Hb, Hct, MCV, MCH, and MCHC than those without haematological disorders. Moreover, the lowest levels of Hb, MCH, and MCHC were observed in the students with haematological disorders who live in the fluoride endemic area. Thus, the excessive fluoride consumption increased haematological alteration in subjects with iron deficiency, thalassaemia, and G-6-PD deficiency and that may increase the risk of anaemia in these subjects. 2018-09-05T03:36:27Z 2018-09-05T03:36:27Z 2017-08-01 Journal 15732983 02694042 2-s2.0-84975141167 10.1007/s10653-016-9845-x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975141167&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57203
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Earth and Planetary Sciences
Environmental Science
spellingShingle Earth and Planetary Sciences
Environmental Science
Sakorn Pornprasert
Phenphichar Wanachantararak
Fahsai Kantawong
Supoj Chamnanprai
Chatpat Kongpan
Nattasit Pienthai
Jintana Yanola
Suwit Duangmano
Mujalin Prasannarong
Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
description © 2016, Springer Science+Business Media Dordrecht. Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still unclear. The fluoride in serum and urine and haematological parameters of students at Mae Tuen School (fluoride endemic area) were analysed and compared to those of students at Baan Yang Poa and Baan Mai Schools (control areas). Iron deficiency, thalassaemia, and G-6-PD deficiency were also diagnosed in these students. The students at Mae Tuen School had significantly (P < 0.001) higher levels of mean fluoride in the serum and urine than those in control areas. In both control and fluoride endemic areas, students with haematological disorders had significantly lower levels of Hb, Hct, MCV, MCH, and MCHC than those without haematological disorders. Moreover, the lowest levels of Hb, MCH, and MCHC were observed in the students with haematological disorders who live in the fluoride endemic area. Thus, the excessive fluoride consumption increased haematological alteration in subjects with iron deficiency, thalassaemia, and G-6-PD deficiency and that may increase the risk of anaemia in these subjects.
format Journal
author Sakorn Pornprasert
Phenphichar Wanachantararak
Fahsai Kantawong
Supoj Chamnanprai
Chatpat Kongpan
Nattasit Pienthai
Jintana Yanola
Suwit Duangmano
Mujalin Prasannarong
author_facet Sakorn Pornprasert
Phenphichar Wanachantararak
Fahsai Kantawong
Supoj Chamnanprai
Chatpat Kongpan
Nattasit Pienthai
Jintana Yanola
Suwit Duangmano
Mujalin Prasannarong
author_sort Sakorn Pornprasert
title Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
title_short Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
title_full Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
title_fullStr Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
title_full_unstemmed Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
title_sort excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (g-6-pd) deficiency
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975141167&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57203
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