Functional contributions of positive charges in the pore‐lining helix 3 of the Bordetella pertussis CyaA- Hemolysin to hemolytic activity and ion-channel opening

• Main Authors: Chattip Kurehong, Chalermpol Kanchanawarin, Busaba Powthongchin, Panchika Prangkio, Gerd Katzenmeier, Chanan Angsuthanasombat
• Format: Journal
• Published: 2018
• Subjects: Environmental Science; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015739334&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/57406
• Institution: Chiang Mai University

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. The Bordetella pertussis CyaA‐hemolysin (CyaA‐Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion‐channel formation in planar lipid bilayers (PLBs). Here, net‐charge variati...