The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery
© 2017 Trans Tech Publications, Switzerland. During surgical procedures on bone, a common method of producing haemostasis at bleeding cancellous bone is the occlusion of blood vessels. This is often achieved with bone wax, which is not bioresorbable, unlike the zein-based biomaterial investigated in...
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th-cmuir.6653943832-574942018-09-05T03:53:52Z The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery Wassanai Wattanutchariya Timothy Quek Suthipas Pongmanee Materials Science Physics and Astronomy © 2017 Trans Tech Publications, Switzerland. During surgical procedures on bone, a common method of producing haemostasis at bleeding cancellous bone is the occlusion of blood vessels. This is often achieved with bone wax, which is not bioresorbable, unlike the zein-based biomaterial investigated in the present research. Zein is a prolamin derived from corn, and has been gaining importance as a bio-medical material. Taking advantage of its solubility in ethanol-water solvents but insolubility in water, a zein-based viscoelastic solid can be produced which effectively occludes the flow of fluids through a porous surface modelling cancellous bone. Zein powder was dissolved into a 70% ethanol-in-water solution, and the ethanol was later leached out through exposure to an alcohol-free media. The insoluble zein ‘resin’ produced could occlude water flow through a porous surface. Experiments were conducted to determine the optimum composition of the precursor zein solution, varying the proportion of zein dissolved in the ethanol-water solvent. A 0.7 w/v composition was selected as the preferred ratio. A cell viability test using the resazurin assay showed that unleached ethanol in the zein-based biomaterial does not pose a threat, as the metabolic activity of osteoblasts on zein resin outperformed that on bone wax after 24 hours of incubation. Subsequent characterisation of the zein resin was performed with a rheometer: results showed that the 0.7 w/v composition had a higher storage modulus and loss modulus for the range of frequencies tested. 2018-09-05T03:43:36Z 2018-09-05T03:43:36Z 2017-01-01 Book Series 16629779 2-s2.0-85032299260 10.4028/www.scientific.net/SSP.266.221 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032299260&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57494 |
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Materials Science Physics and Astronomy Wassanai Wattanutchariya Timothy Quek Suthipas Pongmanee The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
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© 2017 Trans Tech Publications, Switzerland. During surgical procedures on bone, a common method of producing haemostasis at bleeding cancellous bone is the occlusion of blood vessels. This is often achieved with bone wax, which is not bioresorbable, unlike the zein-based biomaterial investigated in the present research. Zein is a prolamin derived from corn, and has been gaining importance as a bio-medical material. Taking advantage of its solubility in ethanol-water solvents but insolubility in water, a zein-based viscoelastic solid can be produced which effectively occludes the flow of fluids through a porous surface modelling cancellous bone. Zein powder was dissolved into a 70% ethanol-in-water solution, and the ethanol was later leached out through exposure to an alcohol-free media. The insoluble zein ‘resin’ produced could occlude water flow through a porous surface. Experiments were conducted to determine the optimum composition of the precursor zein solution, varying the proportion of zein dissolved in the ethanol-water solvent. A 0.7 w/v composition was selected as the preferred ratio. A cell viability test using the resazurin assay showed that unleached ethanol in the zein-based biomaterial does not pose a threat, as the metabolic activity of osteoblasts on zein resin outperformed that on bone wax after 24 hours of incubation. Subsequent characterisation of the zein resin was performed with a rheometer: results showed that the 0.7 w/v composition had a higher storage modulus and loss modulus for the range of frequencies tested. |
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Book Series |
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Wassanai Wattanutchariya Timothy Quek Suthipas Pongmanee |
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Wassanai Wattanutchariya Timothy Quek Suthipas Pongmanee |
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Wassanai Wattanutchariya |
title |
The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
title_short |
The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
title_full |
The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
title_fullStr |
The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
title_full_unstemmed |
The biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
title_sort |
biocompatibility and occlusion ability of a zein-based biomaterial for bone surgery |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032299260&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57494 |
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