Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study

© 2017 Article author(s). Aims To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. Methods In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optica...

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Main Authors: Lawrence S. Geyman, Reena A. Garg, Yanin Suwan, Vivek Trivedi, Brian D. Krawitz, Shelley Mo, Alexander Pinhas, Apichat Tantraworasin, Toco Y.P. Chui, Robert Ritch, Richard B. Rosen
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57634
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spelling th-cmuir.6653943832-576342018-09-05T03:50:57Z Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study Lawrence S. Geyman Reena A. Garg Yanin Suwan Vivek Trivedi Brian D. Krawitz Shelley Mo Alexander Pinhas Apichat Tantraworasin Toco Y.P. Chui Robert Ritch Richard B. Rosen Medicine Neuroscience © 2017 Article author(s). Aims To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. Methods In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software. PCD was calculated as a percentage as the ratio of pixels associated with perfused capillaries to the total number of pixels in the corresponding region-of-interest (ROI). Analysis of covariance was used to compare PCD among the subject groups and control for possible covariates. Area under the receiver operating characteristic curve (AROC) and sensitivity at 95% specificity were calculated to assess the capability of PCD to distinguish mild glaucoma from control. The Pearson's product-moment correlation coefficient was used to assess correlations between PCD and circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field mean deviation (MD). Results PCD demonstrated a progressive stepwise decrease from control eyes throughout worsening POAG stage at all ROIs. PCD demonstrated AROC and sensitivity values comparable to cpRNFLT and visual field parameters and exhibited significant correlations with cpRNFLT and MD at all corresponding ROIs. Conclusions PCD displayed significant correlations with morphological and functional indices and exhibited diagnostic capabilities comparable to currently employed clinical variables. Our preliminary results suggest that PCD analysis may prove to be a useful tool in monitoring POAG across stage and identifying early POAG. 2018-09-05T03:47:13Z 2018-09-05T03:47:13Z 2017-09-01 Journal 14682079 00071161 2-s2.0-85013478429 10.1136/bjophthalmol-2016-309642 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85013478429&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57634
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Lawrence S. Geyman
Reena A. Garg
Yanin Suwan
Vivek Trivedi
Brian D. Krawitz
Shelley Mo
Alexander Pinhas
Apichat Tantraworasin
Toco Y.P. Chui
Robert Ritch
Richard B. Rosen
Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
description © 2017 Article author(s). Aims To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. Methods In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software. PCD was calculated as a percentage as the ratio of pixels associated with perfused capillaries to the total number of pixels in the corresponding region-of-interest (ROI). Analysis of covariance was used to compare PCD among the subject groups and control for possible covariates. Area under the receiver operating characteristic curve (AROC) and sensitivity at 95% specificity were calculated to assess the capability of PCD to distinguish mild glaucoma from control. The Pearson's product-moment correlation coefficient was used to assess correlations between PCD and circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field mean deviation (MD). Results PCD demonstrated a progressive stepwise decrease from control eyes throughout worsening POAG stage at all ROIs. PCD demonstrated AROC and sensitivity values comparable to cpRNFLT and visual field parameters and exhibited significant correlations with cpRNFLT and MD at all corresponding ROIs. Conclusions PCD displayed significant correlations with morphological and functional indices and exhibited diagnostic capabilities comparable to currently employed clinical variables. Our preliminary results suggest that PCD analysis may prove to be a useful tool in monitoring POAG across stage and identifying early POAG.
format Journal
author Lawrence S. Geyman
Reena A. Garg
Yanin Suwan
Vivek Trivedi
Brian D. Krawitz
Shelley Mo
Alexander Pinhas
Apichat Tantraworasin
Toco Y.P. Chui
Robert Ritch
Richard B. Rosen
author_facet Lawrence S. Geyman
Reena A. Garg
Yanin Suwan
Vivek Trivedi
Brian D. Krawitz
Shelley Mo
Alexander Pinhas
Apichat Tantraworasin
Toco Y.P. Chui
Robert Ritch
Richard B. Rosen
author_sort Lawrence S. Geyman
title Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
title_short Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
title_full Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
title_fullStr Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
title_full_unstemmed Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study
title_sort peripapillary perfused capillary density in primary open - angle glaucoma across disease stage: an optical coherence tomography angiography study
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85013478429&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57634
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