7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds

© 2017 S. Karger AG, Basel. Purpose: We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity. Methods: Healthy participants underwent mf...

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Main Authors: Etienne M. Schönbach, Voraporn Chaikitmongkol, Rachel Annam, Emma C. McDonnell, Yulia Wolfson, Emily Fletcher, Hendrik P.N. Scholl
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57675
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-576752018-09-05T03:50:58Z 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds Etienne M. Schönbach Voraporn Chaikitmongkol Rachel Annam Emma C. McDonnell Yulia Wolfson Emily Fletcher Hendrik P.N. Scholl Medicine Neuroscience © 2017 S. Karger AG, Basel. Purpose: We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity. Methods: Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained. Results: A total of 13 subjects (mean age 46.9 years) were included. The median response densities were 12.5 nV/deg2 in the center and 5.2 nV/deg2 in the periphery. Intereye correlations were strong in both the center (ρCenter = 0.821; p < 0.0001) and the periphery (ρPeriphery = 0.862; p < 0.0001). Intraeye correlations were even stronger: ρCenter = 0.904 with p < 0.0001 and ρPeriphery = 0.955 with p < 0.0001. Bland-Altman plots demonstrated an acceptable retest mean difference in both the center and periphery, and narrow limits of agreement. We found strong correlations of the center (ρCenter = 0.826; p < 0.0001) and periphery (ρPeriphery = 0.848; p < 0.0001), with recordings obtained by the 61-hexagon method. Conclusions: The 7-hexagon mfERG provides reproducible results in agreement with results obtained according to the ISCEV standard. 2018-09-05T03:47:53Z 2018-09-05T03:47:53Z 2017-07-01 Journal 14230259 00303747 2-s2.0-85021086820 10.1159/000475996 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021086820&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57675
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Etienne M. Schönbach
Voraporn Chaikitmongkol
Rachel Annam
Emma C. McDonnell
Yulia Wolfson
Emily Fletcher
Hendrik P.N. Scholl
7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
description © 2017 S. Karger AG, Basel. Purpose: We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity. Methods: Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained. Results: A total of 13 subjects (mean age 46.9 years) were included. The median response densities were 12.5 nV/deg2 in the center and 5.2 nV/deg2 in the periphery. Intereye correlations were strong in both the center (ρCenter = 0.821; p < 0.0001) and the periphery (ρPeriphery = 0.862; p < 0.0001). Intraeye correlations were even stronger: ρCenter = 0.904 with p < 0.0001 and ρPeriphery = 0.955 with p < 0.0001. Bland-Altman plots demonstrated an acceptable retest mean difference in both the center and periphery, and narrow limits of agreement. We found strong correlations of the center (ρCenter = 0.826; p < 0.0001) and periphery (ρPeriphery = 0.848; p < 0.0001), with recordings obtained by the 61-hexagon method. Conclusions: The 7-hexagon mfERG provides reproducible results in agreement with results obtained according to the ISCEV standard.
format Journal
author Etienne M. Schönbach
Voraporn Chaikitmongkol
Rachel Annam
Emma C. McDonnell
Yulia Wolfson
Emily Fletcher
Hendrik P.N. Scholl
author_facet Etienne M. Schönbach
Voraporn Chaikitmongkol
Rachel Annam
Emma C. McDonnell
Yulia Wolfson
Emily Fletcher
Hendrik P.N. Scholl
author_sort Etienne M. Schönbach
title 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
title_short 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
title_full 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
title_fullStr 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
title_full_unstemmed 7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
title_sort 7-hexagon multifocal electroretinography for an objective functional assessment of the macula in 14 seconds
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021086820&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57675
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