Development of a multidimensional assessment tool for uraemic pruritus: Uraemic Pruritus in Dialysis Patients (UP-Dial)

• Main Authors: S. Nochaiwong, C. Ruengorn, R. Awiphan, S. Panyathong, K. Noppakun, W. Chongruksut, S. Chiewchanvit
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018977706&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/57687
• Institution: Chiang Mai University

© 2017 British Association of Dermatologists Background: Dialysis patients with uraemic pruritus (UP) have significantly impaired quality of life. To assess the therapeutic effect of UP treatments, a well-validated comprehensive and multidimensional instrument needed to be established. Objectives: To develop and validate a multidimensional scale assessing UP in patients on dialysis: the Uraemic Pruritus in Dialysis Patients (UP-Dial). Methods: The development and validation of the UP-Dial instrument were conducted in four phases: (i) item generation, (ii) development of a pilot questionnaire, (iii) refinement of the questionnaire with patient recruitment and (iv) psychometric validation. Participants completed the UP-Dial, the visual analogue scale (VAS) of UP, the Dermatology Life Quality Index (DLQI), the Kidney Disease Quality of Life-36 (KDQOL-36), the Pittsburgh Sleep Quality Index (PSQI) and the Beck Depression Inventory (BDI) between 15 May 2012 and 30 November 2015. Results: The 27-item pilot UP-Dial was generated, with 168 participants completing the pilot scale. After factor analysis was performed, the final 14-item UP-Dial encompassed three domains: signs and symptoms, psychosocial, and sleep. Face and content validity were satisfied through the item generation process and expert review. Psychometric analysis demonstrated that the UP-Dial had good convergent and discriminant validity. The UP-Dial was significantly correlated [Spearman rank coefficient, 95% confidence interval (CI)] with the VAS-UP (0·76, 0·69–0·83), DLQI (0·78, 0·71–0·85), KDQOL-36 (−0·86, −0·91 to −0·81), PSQI (0·85, 0·80–0·89) and BDI (0·70, 0·61–0·79). The UP-Dial revealed excellent internal consistency (Cronbach's α 0·90, 95% CI 0·87–0·92) and reproducibility (intraclass correlation 0·95, 95% CI 0·90–0·98). Conclusions: The UP-Dial is valid and reliable for assessing UP among patients on dialysis. Future research should focus on the cross-cultural adaptation and translation of the scale to other languages.