Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study

© Europa Digital & Publishing 2017. All rights reserved. Aims: The aim of the study was to investigate long-term changes in lumen eccentricity and asymmetry at five years after implantation of the Absorb bioresorbable vascular scaffold (BVS). Methods and results: Out of 101 patients from the A...

Full description

Saved in:
Bibliographic Details
Main Authors: Pannipa Suwannasom, Yohei Sotomi, Taku Asano, Jaryl Ng Chen Koon, Hiroki Tateishi, Yaping Zeng, Erhan Tenekecioglu, Joanna J. Wykrzykowska, Nicolas Foin, Robbert J. De Winter, John A. Ormiston, Patrick W. Serruys, Yoshinobu Onuma
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017564901&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57729
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-57729
record_format dspace
spelling th-cmuir.6653943832-577292018-09-05T03:48:45Z Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study Pannipa Suwannasom Yohei Sotomi Taku Asano Jaryl Ng Chen Koon Hiroki Tateishi Yaping Zeng Erhan Tenekecioglu Joanna J. Wykrzykowska Nicolas Foin Robbert J. De Winter John A. Ormiston Patrick W. Serruys Yoshinobu Onuma Medicine © Europa Digital & Publishing 2017. All rights reserved. Aims: The aim of the study was to investigate long-term changes in lumen eccentricity and asymmetry at five years after implantation of the Absorb bioresorbable vascular scaffold (BVS). Methods and results: Out of 101 patients from the ABSORB cohort B trial, 28 patients (29 lesions) with serial optical coherence tomography (OCT) examination at four different time points (cohort B1: postprocedure, six months, two, and five years [n=13]; cohort B2: post-procedure, one, three, and five years [n=16]) were evaluated. The longitudinal variance in lumen diameter was assessed by asymmetry index (AI). An asymmetric lesion was defined as AI >0.3. The circularity of the lumen or scaffold was evaluated by the eccentricity index calculated as minimal divided by maximal luminal or scaffold diameter per cross-section. The lowest lumen eccentricity index within a scaffold segment (EIL) <0.7 was defined as an eccentric lesion. Post procedure, an eccentric lesion was observed in 72.4% and became concentric in 93.1% at five years (post EIL 0.67±0.05 vs. five-year EIL 0.80±0.10, p=0.03) with a modest reduction of the lumen area from baseline to five years by 0.75±0.32 mm2. Asymmetric lumen morphology was observed in 93.1% (n=27) post implantation and persisted until five-year follow-up. On serial OCT analyses, there was a substantial increase in the scaffold EI during the first two years (post 0.70±0.06, six months 0.76±0.08, two years 0.85±0.07); then, it remained stable whereas the lumen circularity improved further. There were no significant differences in major adverse cardiac events regarding the lumen morphology over the fiveyear follow-up. Conclusions: In patients treated with the Absorb BVS, the cross-sectional circularity improved over five years while the variance in longitudinal diameters remained. Regaining of lumen circularity is mainly caused by reshaping of the scaffold during the first two years. 2018-09-05T03:48:45Z 2018-09-05T03:48:45Z 2017-04-01 Journal 19696213 1774024X 2-s2.0-85017564901 10.4244/EIJ-D-16-00740 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017564901&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57729
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Pannipa Suwannasom
Yohei Sotomi
Taku Asano
Jaryl Ng Chen Koon
Hiroki Tateishi
Yaping Zeng
Erhan Tenekecioglu
Joanna J. Wykrzykowska
Nicolas Foin
Robbert J. De Winter
John A. Ormiston
Patrick W. Serruys
Yoshinobu Onuma
Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
description © Europa Digital & Publishing 2017. All rights reserved. Aims: The aim of the study was to investigate long-term changes in lumen eccentricity and asymmetry at five years after implantation of the Absorb bioresorbable vascular scaffold (BVS). Methods and results: Out of 101 patients from the ABSORB cohort B trial, 28 patients (29 lesions) with serial optical coherence tomography (OCT) examination at four different time points (cohort B1: postprocedure, six months, two, and five years [n=13]; cohort B2: post-procedure, one, three, and five years [n=16]) were evaluated. The longitudinal variance in lumen diameter was assessed by asymmetry index (AI). An asymmetric lesion was defined as AI >0.3. The circularity of the lumen or scaffold was evaluated by the eccentricity index calculated as minimal divided by maximal luminal or scaffold diameter per cross-section. The lowest lumen eccentricity index within a scaffold segment (EIL) <0.7 was defined as an eccentric lesion. Post procedure, an eccentric lesion was observed in 72.4% and became concentric in 93.1% at five years (post EIL 0.67±0.05 vs. five-year EIL 0.80±0.10, p=0.03) with a modest reduction of the lumen area from baseline to five years by 0.75±0.32 mm2. Asymmetric lumen morphology was observed in 93.1% (n=27) post implantation and persisted until five-year follow-up. On serial OCT analyses, there was a substantial increase in the scaffold EI during the first two years (post 0.70±0.06, six months 0.76±0.08, two years 0.85±0.07); then, it remained stable whereas the lumen circularity improved further. There were no significant differences in major adverse cardiac events regarding the lumen morphology over the fiveyear follow-up. Conclusions: In patients treated with the Absorb BVS, the cross-sectional circularity improved over five years while the variance in longitudinal diameters remained. Regaining of lumen circularity is mainly caused by reshaping of the scaffold during the first two years.
format Journal
author Pannipa Suwannasom
Yohei Sotomi
Taku Asano
Jaryl Ng Chen Koon
Hiroki Tateishi
Yaping Zeng
Erhan Tenekecioglu
Joanna J. Wykrzykowska
Nicolas Foin
Robbert J. De Winter
John A. Ormiston
Patrick W. Serruys
Yoshinobu Onuma
author_facet Pannipa Suwannasom
Yohei Sotomi
Taku Asano
Jaryl Ng Chen Koon
Hiroki Tateishi
Yaping Zeng
Erhan Tenekecioglu
Joanna J. Wykrzykowska
Nicolas Foin
Robbert J. De Winter
John A. Ormiston
Patrick W. Serruys
Yoshinobu Onuma
author_sort Pannipa Suwannasom
title Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
title_short Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
title_full Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
title_fullStr Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
title_full_unstemmed Change in lumen eccentricity and asymmetry after treatment with Absorb bioresorbable vascular scaffolds in the ABSORB cohort B trial: A five-year serial optical coherence tomography imaging study
title_sort change in lumen eccentricity and asymmetry after treatment with absorb bioresorbable vascular scaffolds in the absorb cohort b trial: a five-year serial optical coherence tomography imaging study
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017564901&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57729
_version_ 1681424932974624768