Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database
© 2017 Aranya Manosroi et al. Seven plants in the top rank were selected from the "MANOSROI III" database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildena...
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th-cmuir.6653943832-578222018-09-05T03:50:22Z Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database Aranya Manosroi Theeraphong Tangjai Charinya Chankhampan Worapaka Manosroi Yaravee Najarut Worapong Kitdamrongtham Jiradej Manosroi Medicine © 2017 Aranya Manosroi et al. Seven plants in the top rank were selected from the "MANOSROI III" database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildenafil, a standard anti-impotence drug. Plumbago indica Linn. extract [EDP2-001(1)] exhibited the highest NO release stimulation activity of 666.85% which was 1.50-fold acetylcholine, a standard drug. Most selected plant extracts were nontoxic to EA.hy926 cells at 1.0 mg/mL. EDP1-001(1) exhibited the LD50value of acute oral toxicity in male ICR mice of over 5,000 mg/kg body weight. EDP1-001(1) also indicated the improvement of sexual behaviors in the paroxetine-induced sexual dysfunction male mice with the evaluation of number of courtships (NC), mount frequency (MF), intromission frequency (IF), and ejaculatory frequency (EF) at 87.67±6.17, 121.00±23.50, 36.00±3.21, and 13.67±2.96 which were 2.63-, 1.27-, 0.53-, and 0.62-fold sildenafil-treated mice at day 14 of the treatments, respectively. The present study has not only confirmed the traditional use of Thai plants for the treatment of ED but also indicated the potential and application of the "MANOSROI III" database for Thai plant selection to be developed as ED food supplements. 2018-09-05T03:50:22Z 2018-09-05T03:50:22Z 2017-01-01 Journal 17414288 1741427X 2-s2.0-85027321644 10.1155/2017/9806976 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027321644&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57822 |
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Medicine Aranya Manosroi Theeraphong Tangjai Charinya Chankhampan Worapaka Manosroi Yaravee Najarut Worapong Kitdamrongtham Jiradej Manosroi Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
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© 2017 Aranya Manosroi et al. Seven plants in the top rank were selected from the "MANOSROI III" database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildenafil, a standard anti-impotence drug. Plumbago indica Linn. extract [EDP2-001(1)] exhibited the highest NO release stimulation activity of 666.85% which was 1.50-fold acetylcholine, a standard drug. Most selected plant extracts were nontoxic to EA.hy926 cells at 1.0 mg/mL. EDP1-001(1) exhibited the LD50value of acute oral toxicity in male ICR mice of over 5,000 mg/kg body weight. EDP1-001(1) also indicated the improvement of sexual behaviors in the paroxetine-induced sexual dysfunction male mice with the evaluation of number of courtships (NC), mount frequency (MF), intromission frequency (IF), and ejaculatory frequency (EF) at 87.67±6.17, 121.00±23.50, 36.00±3.21, and 13.67±2.96 which were 2.63-, 1.27-, 0.53-, and 0.62-fold sildenafil-treated mice at day 14 of the treatments, respectively. The present study has not only confirmed the traditional use of Thai plants for the treatment of ED but also indicated the potential and application of the "MANOSROI III" database for Thai plant selection to be developed as ED food supplements. |
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Journal |
author |
Aranya Manosroi Theeraphong Tangjai Charinya Chankhampan Worapaka Manosroi Yaravee Najarut Worapong Kitdamrongtham Jiradej Manosroi |
author_facet |
Aranya Manosroi Theeraphong Tangjai Charinya Chankhampan Worapaka Manosroi Yaravee Najarut Worapong Kitdamrongtham Jiradej Manosroi |
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Aranya Manosroi |
title |
Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
title_short |
Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
title_full |
Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
title_fullStr |
Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
title_full_unstemmed |
Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from "mANOSROI III" Database |
title_sort |
potent phosphodiesterase inhibition and nitric oxide release stimulation of anti-impotence thai medicinal plants from "manosroi iii" database |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027321644&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57822 |
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1681424950144008192 |