Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals

© 2017, Veteriner Fakultesi Dergisi. All rights reserved. Here, we explored the rate of telomere attrition with increasing age by real-time quantitative PCR (qPCR) in a short- (Chihuahua dog) and long(Asian elephant) lived species. A total of 122 Asian elephants (female = 106, male = 16) ranging fro...

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Main Authors: Kittisak Buddhachat, Wannapimol Kriangwanich, Saraporn Kumoun, Janine L. Brown, Sasisophin Chailangkarn, Chaleamchat Somgird, Chatchote Thitaram, Sukon Prasitwattanaseree, Korakot Nganvongpanit
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57956
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-579562018-09-05T03:55:25Z Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals Kittisak Buddhachat Wannapimol Kriangwanich Saraporn Kumoun Janine L. Brown Sasisophin Chailangkarn Chaleamchat Somgird Chatchote Thitaram Sukon Prasitwattanaseree Korakot Nganvongpanit Veterinary © 2017, Veteriner Fakultesi Dergisi. All rights reserved. Here, we explored the rate of telomere attrition with increasing age by real-time quantitative PCR (qPCR) in a short- (Chihuahua dog) and long(Asian elephant) lived species. A total of 122 Asian elephants (female = 106, male = 16) ranging from 24-840 months of age, and 89 Chihuahuas (female = 65, male = 24) 1-179 months of age were used in this study. We found that young (pre- and peri-pubertal) Asian elephants had a higher relative telomere length (RTL) compared to dogs. A low, but significant negative relationship between RTL and increasing age was observed in both Chihuahuas (R2=0.0490, P=0.0017) and Asian elephants (R2=0.0177, P=0.0210). The estimated rate of telomere loss for males and females of both species ranged from -0.0023 to -0.0065, with no clear differences between gender or species. Results suggest that Asian elephants may start with longer telomeres than Chihuahuas, as RTL was higher, but then the rate of telomere attrition proceeds at a similar rate in both species. Age accounted for only a small percentage of the variation in RTL in both Chihuahua dogs and Asian elephants, however. Thus, its use as a biological tool for age estimation would appear to be limited for these species. 2018-09-05T03:55:25Z 2018-09-05T03:55:25Z 2017-01-01 Journal 13092251 13006045 2-s2.0-85018287116 10.9775/kvfd.2017.17504 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018287116&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57956
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Veterinary
spellingShingle Veterinary
Kittisak Buddhachat
Wannapimol Kriangwanich
Saraporn Kumoun
Janine L. Brown
Sasisophin Chailangkarn
Chaleamchat Somgird
Chatchote Thitaram
Sukon Prasitwattanaseree
Korakot Nganvongpanit
Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
description © 2017, Veteriner Fakultesi Dergisi. All rights reserved. Here, we explored the rate of telomere attrition with increasing age by real-time quantitative PCR (qPCR) in a short- (Chihuahua dog) and long(Asian elephant) lived species. A total of 122 Asian elephants (female = 106, male = 16) ranging from 24-840 months of age, and 89 Chihuahuas (female = 65, male = 24) 1-179 months of age were used in this study. We found that young (pre- and peri-pubertal) Asian elephants had a higher relative telomere length (RTL) compared to dogs. A low, but significant negative relationship between RTL and increasing age was observed in both Chihuahuas (R2=0.0490, P=0.0017) and Asian elephants (R2=0.0177, P=0.0210). The estimated rate of telomere loss for males and females of both species ranged from -0.0023 to -0.0065, with no clear differences between gender or species. Results suggest that Asian elephants may start with longer telomeres than Chihuahuas, as RTL was higher, but then the rate of telomere attrition proceeds at a similar rate in both species. Age accounted for only a small percentage of the variation in RTL in both Chihuahua dogs and Asian elephants, however. Thus, its use as a biological tool for age estimation would appear to be limited for these species.
format Journal
author Kittisak Buddhachat
Wannapimol Kriangwanich
Saraporn Kumoun
Janine L. Brown
Sasisophin Chailangkarn
Chaleamchat Somgird
Chatchote Thitaram
Sukon Prasitwattanaseree
Korakot Nganvongpanit
author_facet Kittisak Buddhachat
Wannapimol Kriangwanich
Saraporn Kumoun
Janine L. Brown
Sasisophin Chailangkarn
Chaleamchat Somgird
Chatchote Thitaram
Sukon Prasitwattanaseree
Korakot Nganvongpanit
author_sort Kittisak Buddhachat
title Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
title_short Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
title_full Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
title_fullStr Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
title_full_unstemmed Telomeric attrition with increasing age in short- (Chihuahua dog) and long- (Asian elephant) life span animals
title_sort telomeric attrition with increasing age in short- (chihuahua dog) and long- (asian elephant) life span animals
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018287116&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57956
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