Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii
© 2017 Phytochemical Society of Europe Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thoreli...
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th-cmuir.6653943832-581262018-09-05T04:22:24Z Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii Thanika Promchai Tongchai Saesong Kornkanok Ingkaninan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul (née Ritthiwigrom) Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology © 2017 Phytochemical Society of Europe Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thorelii. The structures of all isolated compounds were elucidated by spectroscopic methods and mass spectrometry. All compounds were evaluated for their acetylcholinesterase activities. Miliusathorine A (1) and norushisunine had the best AChE inhibitory activities, however these were weak inhibitors when compared to the standard galantamine. 2018-09-05T04:20:12Z 2018-09-05T04:20:12Z 2018-02-01 Journal 18767486 18743900 2-s2.0-85033601611 10.1016/j.phytol.2017.11.010 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033601611&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58126 |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Thanika Promchai Tongchai Saesong Kornkanok Ingkaninan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul (née Ritthiwigrom) Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
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© 2017 Phytochemical Society of Europe Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thorelii. The structures of all isolated compounds were elucidated by spectroscopic methods and mass spectrometry. All compounds were evaluated for their acetylcholinesterase activities. Miliusathorine A (1) and norushisunine had the best AChE inhibitory activities, however these were weak inhibitors when compared to the standard galantamine. |
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author |
Thanika Promchai Tongchai Saesong Kornkanok Ingkaninan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul (née Ritthiwigrom) |
author_facet |
Thanika Promchai Tongchai Saesong Kornkanok Ingkaninan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul (née Ritthiwigrom) |
author_sort |
Thanika Promchai |
title |
Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
title_short |
Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
title_full |
Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
title_fullStr |
Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
title_full_unstemmed |
Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii |
title_sort |
acetylcholinesterase inhibitory activity of chemical constituents isolated from miliusa thorelii |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033601611&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58126 |
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