Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

© 2017 Wiley Periodicals, Inc. Thalassemia is among the most common genetic diseases worldwide. Ineffective erythropoiesis, chronic hemolysis, and regular blood transfusion in thalassemia patients lead to increased iron burden. Iron overload cardiomyopathy is the most severe co-morbidity and most co...

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Main Authors: Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/58221
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-582212018-09-05T04:21:18Z Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy Natthaphat Siri-Angkul Siriporn C. Chattipakorn Nipon Chattipakorn Biochemistry, Genetics and Molecular Biology © 2017 Wiley Periodicals, Inc. Thalassemia is among the most common genetic diseases worldwide. Ineffective erythropoiesis, chronic hemolysis, and regular blood transfusion in thalassemia patients lead to increased iron burden. Iron overload cardiomyopathy is the most severe co-morbidity and most common cause of mortality in thalassemia patients. Although its associated mechanisms are still not completely understood, cellular iron mishandling, chronic inflammation, and oxidative stress appear to be the key processes involved. In order to acquire a more comprehensive insight of the impact of cardiac iron overload, these alterations need to be intensively investigated. This comprehensive mini-review focuses on two emergent molecules which have been shown to potentially play significant roles in iron overload cardiomyopathy. These two molecules are an iron-transporting protein, lipocalin 2, and an anti-inflammatory adipokine, adiponectin. Reports from in vitro and in vivo studies are comprehensively summarized. Clinical studies examining the roles of these molecules in thalassemia patients are also presented and discussed. 2018-09-05T04:21:18Z 2018-09-05T04:21:18Z 2018-07-01 Journal 10974652 00219541 2-s2.0-85040865731 10.1002/jcp.26318 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040865731&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58221
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Natthaphat Siri-Angkul
Siriporn C. Chattipakorn
Nipon Chattipakorn
Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
description © 2017 Wiley Periodicals, Inc. Thalassemia is among the most common genetic diseases worldwide. Ineffective erythropoiesis, chronic hemolysis, and regular blood transfusion in thalassemia patients lead to increased iron burden. Iron overload cardiomyopathy is the most severe co-morbidity and most common cause of mortality in thalassemia patients. Although its associated mechanisms are still not completely understood, cellular iron mishandling, chronic inflammation, and oxidative stress appear to be the key processes involved. In order to acquire a more comprehensive insight of the impact of cardiac iron overload, these alterations need to be intensively investigated. This comprehensive mini-review focuses on two emergent molecules which have been shown to potentially play significant roles in iron overload cardiomyopathy. These two molecules are an iron-transporting protein, lipocalin 2, and an anti-inflammatory adipokine, adiponectin. Reports from in vitro and in vivo studies are comprehensively summarized. Clinical studies examining the roles of these molecules in thalassemia patients are also presented and discussed.
format Journal
author Natthaphat Siri-Angkul
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_facet Natthaphat Siri-Angkul
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_sort Natthaphat Siri-Angkul
title Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
title_short Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
title_full Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
title_fullStr Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
title_full_unstemmed Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
title_sort roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040865731&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58221
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