A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases

© 2018 by the Asian Pacific Journal of Tropical Biomedicine. The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The suppleme...

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Main Author: Bhagavathi Sundaram Sivamaruthi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/58280
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spelling th-cmuir.6653943832-582802018-09-05T04:22:06Z A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases Bhagavathi Sundaram Sivamaruthi Biochemistry, Genetics and Molecular Biology © 2018 by the Asian Pacific Journal of Tropical Biomedicine. The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The supplementation of probiotics and synbiotic could indeed manipulate the microflora, which can be an alternative therapy for ulcerative colitis, and Crohn's disease. Several in vitro, in vivo and clinical studies for the initiation and maintenance of remission in patients with inflammatory bowel disease have been completed. Those studies evaluated the efficacy of many probiotic formulations, especially about VSL#3. Even though the clinical studies proved that almost all the probiotic interventions are safe and bring improvement to patients, some studies are deficient in sample size, proper controls, and follow-ups. This paper summarizes the possible mechanism of inflammatory bowel disease development, probiotics, the clinical outcome of probiotic and synbiotic interventions for ulcerative colitis and Crohn's disease, as well as the adverse effect of probiotic treatments. 2018-09-05T04:22:06Z 2018-09-05T04:22:06Z 2018-03-01 Journal 22211691 2-s2.0-85044431266 10.4103/2221-1691.228000 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044431266&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58280
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Bhagavathi Sundaram Sivamaruthi
A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
description © 2018 by the Asian Pacific Journal of Tropical Biomedicine. The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The supplementation of probiotics and synbiotic could indeed manipulate the microflora, which can be an alternative therapy for ulcerative colitis, and Crohn's disease. Several in vitro, in vivo and clinical studies for the initiation and maintenance of remission in patients with inflammatory bowel disease have been completed. Those studies evaluated the efficacy of many probiotic formulations, especially about VSL#3. Even though the clinical studies proved that almost all the probiotic interventions are safe and bring improvement to patients, some studies are deficient in sample size, proper controls, and follow-ups. This paper summarizes the possible mechanism of inflammatory bowel disease development, probiotics, the clinical outcome of probiotic and synbiotic interventions for ulcerative colitis and Crohn's disease, as well as the adverse effect of probiotic treatments.
format Journal
author Bhagavathi Sundaram Sivamaruthi
author_facet Bhagavathi Sundaram Sivamaruthi
author_sort Bhagavathi Sundaram Sivamaruthi
title A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
title_short A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
title_full A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
title_fullStr A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
title_full_unstemmed A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
title_sort comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044431266&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58280
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