A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

• Main Authors: Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038612085&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/58309
• Institution: Chiang Mai University

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Many recent studies have shown that antioxidant compounds decrease cardiac oxidative stress, decrease cardiac iron deposition, and improve cardiac dysfunction in iron-overload induced cardiomyopathy in animal models. Interestingly,...