Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

© 2017 Elsevier B.V. and Mitochondria Research Society Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischem...

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Main Authors: Savitree Thummasorn, Krekwit Shinlapawittayatorn, Juthamas Khamseekaew, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58312
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-583122018-09-05T04:22:33Z Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity Savitree Thummasorn Krekwit Shinlapawittayatorn Juthamas Khamseekaew Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn Biochemistry, Genetics and Molecular Biology © 2017 Elsevier B.V. and Mitochondria Research Society Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against oxidative stress. Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H2O2) induced oxidative stress in isolated cardiac mitochondria. We found that HNG has direct protective effects on cardiac mitochondrial function against H2O2induced oxidative stress through decreasing complex I activity. 2018-09-05T04:22:33Z 2018-09-05T04:22:33Z 2018-01-01 Journal 18728278 15677249 2-s2.0-85027396732 10.1016/j.mito.2017.08.001 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58312
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Savitree Thummasorn
Krekwit Shinlapawittayatorn
Juthamas Khamseekaew
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
description © 2017 Elsevier B.V. and Mitochondria Research Society Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against oxidative stress. Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H2O2) induced oxidative stress in isolated cardiac mitochondria. We found that HNG has direct protective effects on cardiac mitochondrial function against H2O2induced oxidative stress through decreasing complex I activity.
format Journal
author Savitree Thummasorn
Krekwit Shinlapawittayatorn
Juthamas Khamseekaew
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_facet Savitree Thummasorn
Krekwit Shinlapawittayatorn
Juthamas Khamseekaew
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_sort Savitree Thummasorn
title Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_short Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_full Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_fullStr Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_full_unstemmed Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_sort humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex i activity
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58312
_version_ 1681425041837785088

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