A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity

© 2018 by the authors. Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-...

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Main Authors:	Wongvarit Panidthananon, Tanawat Chaowasku, Boonchoo Sritularak, Kittisak Likhitwitayawuid
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049451194&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58328
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-583282018-09-05T04:38:27Z A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity Wongvarit Panidthananon Tanawat Chaowasku Boonchoo Sritularak Kittisak Likhitwitayawuid Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics © 2018 by the authors. Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme. 2018-09-05T04:22:46Z 2018-09-05T04:22:46Z 2018-01-01 Journal 14203049 2-s2.0-85049451194 10.3390/molecules23071600 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049451194&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58328
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Wongvarit Panidthananon Tanawat Chaowasku Boonchoo Sritularak Kittisak Likhitwitayawuid A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
description	© 2018 by the authors. Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme.
format	Journal
author	Wongvarit Panidthananon Tanawat Chaowasku Boonchoo Sritularak Kittisak Likhitwitayawuid
author_facet	Wongvarit Panidthananon Tanawat Chaowasku Boonchoo Sritularak Kittisak Likhitwitayawuid
author_sort	Wongvarit Panidthananon
title	A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
title_short	A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
title_full	A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
title_fullStr	A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
title_full_unstemmed	A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
title_sort	new benzophenone c-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049451194&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58328
_version_	1681425044807352320

A new benzophenone C-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity

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