5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts
© 2018, Chiang Mai University. All rights reserved. Five selected Thai plant extracts, including Lotus seeds, Black Sesame seeds, White Kwao Krua tubers, rice bran and Asiatic Pennywort leaves were extracted by different solvents (ethyl acetate, ethanol and water). The mixture of the rice bran extra...
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th-cmuir.6653943832-583462018-09-05T04:39:53Z 5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts Aranya Manosroi Puxvadee Chaikul Charinya Chankhampan Warintorn Ruksiriwanich Worapaka Manosroi Jiradej Manosroi Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy © 2018, Chiang Mai University. All rights reserved. Five selected Thai plant extracts, including Lotus seeds, Black Sesame seeds, White Kwao Krua tubers, rice bran and Asiatic Pennywort leaves were extracted by different solvents (ethyl acetate, ethanol and water). The mixture of the rice bran extract and the White Kwao Krua extract at 1:1 weight ratio, the water and chloroform fractions of the decolorized Asiatic Pennywort extract and the rice bran extract loaded in β-cyclodextrin were prepared. The samples were investigated for 5α-reductase inhibition in DU-145 prostate carcinoma and melanogenesis in B16F10 melanoma cells. The rice bran extract not loaded and loaded in β-cyclodextrin exhibited the high linoleic acid contents of 21.13±1.22 and 21.47±0.91% w/w, respectively. The highest inhibitory effect of 5α-reductase type 1 was observed in 0.5 mg/mL of the rice bran extract at 87.43±7.15% of the control, which was higher than the standard dutasteride of about 1.60 times, followed respectively by the mixture of the rice bran extract and the White Kwao Krua extract, and the Lotus seed extract. The rice bran extract loaded in β-cyclodextrin at 1 mg/mL and the White Kwao Krua n-hexane fraction at 1 mg/mL demonstrated the highest melanogenesis induction and tyrosinase activity of 1.25 and 1.82 folds of the control, and 0.52 and 0.55 folds of the standard theophylline, respectively. This study has demonstrated the potential of the rice bran extracts on 5α-reductase inhibition and melanogenesis induction when loaded in β-cyclodextrin, which can be further developed as the anti-hair loss and hair darkening products. 2018-09-05T04:22:59Z 2018-09-05T04:22:59Z 2018-01-01 Journal 01252526 2-s2.0-85040945377 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040945377&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58346 |
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Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy Aranya Manosroi Puxvadee Chaikul Charinya Chankhampan Warintorn Ruksiriwanich Worapaka Manosroi Jiradej Manosroi 5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
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© 2018, Chiang Mai University. All rights reserved. Five selected Thai plant extracts, including Lotus seeds, Black Sesame seeds, White Kwao Krua tubers, rice bran and Asiatic Pennywort leaves were extracted by different solvents (ethyl acetate, ethanol and water). The mixture of the rice bran extract and the White Kwao Krua extract at 1:1 weight ratio, the water and chloroform fractions of the decolorized Asiatic Pennywort extract and the rice bran extract loaded in β-cyclodextrin were prepared. The samples were investigated for 5α-reductase inhibition in DU-145 prostate carcinoma and melanogenesis in B16F10 melanoma cells. The rice bran extract not loaded and loaded in β-cyclodextrin exhibited the high linoleic acid contents of 21.13±1.22 and 21.47±0.91% w/w, respectively. The highest inhibitory effect of 5α-reductase type 1 was observed in 0.5 mg/mL of the rice bran extract at 87.43±7.15% of the control, which was higher than the standard dutasteride of about 1.60 times, followed respectively by the mixture of the rice bran extract and the White Kwao Krua extract, and the Lotus seed extract. The rice bran extract loaded in β-cyclodextrin at 1 mg/mL and the White Kwao Krua n-hexane fraction at 1 mg/mL demonstrated the highest melanogenesis induction and tyrosinase activity of 1.25 and 1.82 folds of the control, and 0.52 and 0.55 folds of the standard theophylline, respectively. This study has demonstrated the potential of the rice bran extracts on 5α-reductase inhibition and melanogenesis induction when loaded in β-cyclodextrin, which can be further developed as the anti-hair loss and hair darkening products. |
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Journal |
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Aranya Manosroi Puxvadee Chaikul Charinya Chankhampan Warintorn Ruksiriwanich Worapaka Manosroi Jiradej Manosroi |
author_facet |
Aranya Manosroi Puxvadee Chaikul Charinya Chankhampan Warintorn Ruksiriwanich Worapaka Manosroi Jiradej Manosroi |
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Aranya Manosroi |
title |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
title_short |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
title_full |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
title_fullStr |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
title_full_unstemmed |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
title_sort |
5α-reductase inhibition and melanogenesis induction of the selected thai plant extracts |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040945377&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58346 |
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