Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats

© 2018 Wiley Periodicals, Inc. Electrospinning of a biodegradable polymer blend of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) is reported for the first time. Effects of several solution parameters on electrospinning are explored, including types of single and binary s...

Full description

Saved in:
Bibliographic Details
Main Authors: Sarunphat Khatsee, Donraporn Daranarong, Winita Punyodom, Patnarin Worajittiphon
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044770013&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58444
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-58444
record_format dspace
spelling th-cmuir.6653943832-584442018-09-05T04:31:02Z Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats Sarunphat Khatsee Donraporn Daranarong Winita Punyodom Patnarin Worajittiphon Chemistry Materials Science © 2018 Wiley Periodicals, Inc. Electrospinning of a biodegradable polymer blend of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) is reported for the first time. Effects of several solution parameters on electrospinning are explored, including types of single and binary solvents, binary solvent mixing ratio, polymer blend concentration, polymer blending ratio, and loading content of tetrabutyl titanate as a compatibilizer. An electrospinnability–solubility map of the PLA/PBAT blend is firstly developed for the facile selection of a suitable binary solvent system, thus simplifying the laborious, time-consuming, trial-and-error process. A particular binary solvent system derived from good and non-solvent serves as the most suitable medium for the successful preparation of homogeneous bead-free electrospun PLA/PBAT nanofibers. It is revealed that the compatibilizer acts not only as a diameter size tuner for the PLA/PBAT fibers but also as a mechanical property enhancer for the immiscible PLA/PBAT electrospun mats. Moreover, the antibacterial activity of the drug-loaded PLA/PBAT fibrous mats suggests their potential application as antibiotic-carrier mats. Preparation of the composite mats comprising bead-free fibers with an average size at sub-micrometer scale is also demonstrated, additionally promoting the possibility of using the PLA/PBAT-based electrospun mats as a matrix of various additives for a wide range of applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46486. 2018-09-05T04:24:09Z 2018-09-05T04:24:09Z 2018-07-20 Journal 10974628 00218995 2-s2.0-85044770013 10.1002/app.46486 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044770013&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58444
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemistry
Materials Science
spellingShingle Chemistry
Materials Science
Sarunphat Khatsee
Donraporn Daranarong
Winita Punyodom
Patnarin Worajittiphon
Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
description © 2018 Wiley Periodicals, Inc. Electrospinning of a biodegradable polymer blend of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) is reported for the first time. Effects of several solution parameters on electrospinning are explored, including types of single and binary solvents, binary solvent mixing ratio, polymer blend concentration, polymer blending ratio, and loading content of tetrabutyl titanate as a compatibilizer. An electrospinnability–solubility map of the PLA/PBAT blend is firstly developed for the facile selection of a suitable binary solvent system, thus simplifying the laborious, time-consuming, trial-and-error process. A particular binary solvent system derived from good and non-solvent serves as the most suitable medium for the successful preparation of homogeneous bead-free electrospun PLA/PBAT nanofibers. It is revealed that the compatibilizer acts not only as a diameter size tuner for the PLA/PBAT fibers but also as a mechanical property enhancer for the immiscible PLA/PBAT electrospun mats. Moreover, the antibacterial activity of the drug-loaded PLA/PBAT fibrous mats suggests their potential application as antibiotic-carrier mats. Preparation of the composite mats comprising bead-free fibers with an average size at sub-micrometer scale is also demonstrated, additionally promoting the possibility of using the PLA/PBAT-based electrospun mats as a matrix of various additives for a wide range of applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46486.
format Journal
author Sarunphat Khatsee
Donraporn Daranarong
Winita Punyodom
Patnarin Worajittiphon
author_facet Sarunphat Khatsee
Donraporn Daranarong
Winita Punyodom
Patnarin Worajittiphon
author_sort Sarunphat Khatsee
title Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
title_short Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
title_full Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
title_fullStr Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
title_full_unstemmed Electrospinning polymer blend of PLA and PBAT: Electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
title_sort electrospinning polymer blend of pla and pbat: electrospinnability–solubility map and effect of polymer solution parameters toward application as antibiotic-carrier mats
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044770013&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58444
_version_ 1681425066476175360