Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design

© 2018 Objective: The main objective of the study was to measure the levels of plasma β-endorphin (PB) and plasma cortisol (PC) under lumbar core stabilization exercise (LCSE), placebo and control conditions in patients with chronic nonspecific low back pain. Methods: Twenty-four participants with c...

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Main Authors: Aatit Paungmali, Leonard Henry Joseph, Khanittha Punturee, Patraporn Sitilertpisan, Ubon Pirunsan, Sureeporn Uthaikhup
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/58748
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-587482018-09-05T04:30:10Z Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design Aatit Paungmali Leonard Henry Joseph Khanittha Punturee Patraporn Sitilertpisan Ubon Pirunsan Sureeporn Uthaikhup Health Professions © 2018 Objective: The main objective of the study was to measure the levels of plasma β-endorphin (PB) and plasma cortisol (PC) under lumbar core stabilization exercise (LCSE), placebo and control conditions in patients with chronic nonspecific low back pain. Methods: Twenty-four participants with chronic nonspecific low back pain participated in a randomized, placebo-controlled, crossover design study. There were 3 experimental exercise conditions: control condition (positioning in crook lying and rest), placebo condition (passive cycling in crook lying using automatic cycler), and LCSE on a Pilates device tested with a 48-hour interval between sessions by concealed randomization. A blood sample was collected before and after the exercise conditions. Plasma β-endorphin and PC were measured through enzyme-linked immunosorbent assay and electrochemiluminescence in a Cobas E411 auto analyzer. Results: A significant difference in PB level was identified before and after the LCSE condition (P <.05), whereas no significant differences were noted in control and placebo exercise conditions. Also, the trend of elevation of PB under the LCSE was significantly different compared with the placebo and control conditions (P <.01). In contrast, the PC level remained unchanged in all 3 conditions. Conclusion: The findings of this study indicate that LCSE could possibly influence PB but not PC level among patients with chronic nonspecific low back pain. The mechanism of action of the pain-relieving effect of LCSE might be related to an endogenous opioid mechanism as part of its effects and might not be involved with a stress-induced analgesia mechanism. 2018-09-05T04:30:10Z 2018-09-05T04:30:10Z 2018-03-01 Journal 15326586 01614754 2-s2.0-85042069894 10.1016/j.jmpt.2018.01.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042069894&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58748
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Health Professions
spellingShingle Health Professions
Aatit Paungmali
Leonard Henry Joseph
Khanittha Punturee
Patraporn Sitilertpisan
Ubon Pirunsan
Sureeporn Uthaikhup
Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
description © 2018 Objective: The main objective of the study was to measure the levels of plasma β-endorphin (PB) and plasma cortisol (PC) under lumbar core stabilization exercise (LCSE), placebo and control conditions in patients with chronic nonspecific low back pain. Methods: Twenty-four participants with chronic nonspecific low back pain participated in a randomized, placebo-controlled, crossover design study. There were 3 experimental exercise conditions: control condition (positioning in crook lying and rest), placebo condition (passive cycling in crook lying using automatic cycler), and LCSE on a Pilates device tested with a 48-hour interval between sessions by concealed randomization. A blood sample was collected before and after the exercise conditions. Plasma β-endorphin and PC were measured through enzyme-linked immunosorbent assay and electrochemiluminescence in a Cobas E411 auto analyzer. Results: A significant difference in PB level was identified before and after the LCSE condition (P <.05), whereas no significant differences were noted in control and placebo exercise conditions. Also, the trend of elevation of PB under the LCSE was significantly different compared with the placebo and control conditions (P <.01). In contrast, the PC level remained unchanged in all 3 conditions. Conclusion: The findings of this study indicate that LCSE could possibly influence PB but not PC level among patients with chronic nonspecific low back pain. The mechanism of action of the pain-relieving effect of LCSE might be related to an endogenous opioid mechanism as part of its effects and might not be involved with a stress-induced analgesia mechanism.
format Journal
author Aatit Paungmali
Leonard Henry Joseph
Khanittha Punturee
Patraporn Sitilertpisan
Ubon Pirunsan
Sureeporn Uthaikhup
author_facet Aatit Paungmali
Leonard Henry Joseph
Khanittha Punturee
Patraporn Sitilertpisan
Ubon Pirunsan
Sureeporn Uthaikhup
author_sort Aatit Paungmali
title Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
title_short Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
title_full Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
title_fullStr Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
title_full_unstemmed Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design
title_sort immediate effects of core stabilization exercise on β-endorphin and cortisol levels among patients with chronic nonspecific low back pain: a randomized crossover design
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042069894&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58748
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