The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum

© 2018 Informa UK Limited, trading as Taylor & Francis Group Objectives: The aim of this study was to investigate physical decline over 1-year in a cohort of older people across the cognitive spectrum. Methods: Physical function was assessed using the Physiological Profile Assessment (PPA) in...

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Main Authors: Morag E. Taylor, Sirinun Boripuntakul, Barbara Toson, Jacqueline C.T. Close, Stephen R. Lord, Nicole A. Kochan, Perminder S. Sachdev, Henry Brodaty, Kim Delbaere
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/58934
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-589342018-09-05T04:37:42Z The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum Morag E. Taylor Sirinun Boripuntakul Barbara Toson Jacqueline C.T. Close Stephen R. Lord Nicole A. Kochan Perminder S. Sachdev Henry Brodaty Kim Delbaere Medicine Nursing © 2018 Informa UK Limited, trading as Taylor & Francis Group Objectives: The aim of this study was to investigate physical decline over 1-year in a cohort of older people across the cognitive spectrum. Methods: Physical function was assessed using the Physiological Profile Assessment (PPA) in 593 participants (cognitively normal [CN]: n = 342, mild cognitive impairment [MCI]: n = 77, dementia: n = 174) at baseline and in 490 participants available for reassessment 1-year later. Neuropsychological performance and physical activity (PA) were assessed at baseline. Results: Median baseline PPA scores for CN, MCI and dementia groups were 0.41 (IQR = −0.09–1.02), 0.66 (IQR = −0.06–1.15) and 2.37 (IQR = 0.93–3.78) respectively. All baseline neuropsychological domains and PA were significantly associated with baseline PPA. There were significant interaction terms (Time × Cognitive Group, Global Cognition, Processing Speed, Executive Function and PA) in the models investigating PPA decline. In multivariate analysis the Time × Executive Function and PA interaction terms were significant, indicating that participants with poorer baseline executive function and reduced PA demonstrated greater physical decline when compared to individuals with better executive function and PA respectively. Discussion: Having MCI or dementia is associated with greater physical decline compared to CN older people. Physical inactivity and executive dysfunction were associated with physical decline in this sample, which included participants with MCI and dementia. Both factors influencing physical decline are potentially amenable to interventions e.g. exercise. 2018-09-05T04:35:16Z 2018-09-05T04:35:16Z 2018-05-01 Journal 13646915 13607863 2-s2.0-85047419994 10.1080/13607863.2018.1474446 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047419994&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58934
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Nursing
spellingShingle Medicine
Nursing
Morag E. Taylor
Sirinun Boripuntakul
Barbara Toson
Jacqueline C.T. Close
Stephen R. Lord
Nicole A. Kochan
Perminder S. Sachdev
Henry Brodaty
Kim Delbaere
The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
description © 2018 Informa UK Limited, trading as Taylor & Francis Group Objectives: The aim of this study was to investigate physical decline over 1-year in a cohort of older people across the cognitive spectrum. Methods: Physical function was assessed using the Physiological Profile Assessment (PPA) in 593 participants (cognitively normal [CN]: n = 342, mild cognitive impairment [MCI]: n = 77, dementia: n = 174) at baseline and in 490 participants available for reassessment 1-year later. Neuropsychological performance and physical activity (PA) were assessed at baseline. Results: Median baseline PPA scores for CN, MCI and dementia groups were 0.41 (IQR = −0.09–1.02), 0.66 (IQR = −0.06–1.15) and 2.37 (IQR = 0.93–3.78) respectively. All baseline neuropsychological domains and PA were significantly associated with baseline PPA. There were significant interaction terms (Time × Cognitive Group, Global Cognition, Processing Speed, Executive Function and PA) in the models investigating PPA decline. In multivariate analysis the Time × Executive Function and PA interaction terms were significant, indicating that participants with poorer baseline executive function and reduced PA demonstrated greater physical decline when compared to individuals with better executive function and PA respectively. Discussion: Having MCI or dementia is associated with greater physical decline compared to CN older people. Physical inactivity and executive dysfunction were associated with physical decline in this sample, which included participants with MCI and dementia. Both factors influencing physical decline are potentially amenable to interventions e.g. exercise.
format Journal
author Morag E. Taylor
Sirinun Boripuntakul
Barbara Toson
Jacqueline C.T. Close
Stephen R. Lord
Nicole A. Kochan
Perminder S. Sachdev
Henry Brodaty
Kim Delbaere
author_facet Morag E. Taylor
Sirinun Boripuntakul
Barbara Toson
Jacqueline C.T. Close
Stephen R. Lord
Nicole A. Kochan
Perminder S. Sachdev
Henry Brodaty
Kim Delbaere
author_sort Morag E. Taylor
title The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
title_short The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
title_full The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
title_fullStr The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
title_full_unstemmed The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
title_sort role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047419994&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58934
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