Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study

Copyright © 2017 Asia-Pacific Academy of Ophthalmology. Unauthorized reproduction of this article is prohibited. Purpose: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and cont...

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Main Authors: Yanin Suwan, Lawrence S. Geyman, Masoud Aghsaei Fard, Apichat Tantraworasin, Toco Y. Chui, Richard B. Rosen, Robert Ritch
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/58984
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spelling th-cmuir.6653943832-589842018-09-05T04:35:57Z Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study Yanin Suwan Lawrence S. Geyman Masoud Aghsaei Fard Apichat Tantraworasin Toco Y. Chui Richard B. Rosen Robert Ritch Medicine Copyright © 2017 Asia-Pacific Academy of Ophthalmology. Unauthorized reproduction of this article is prohibited. Purpose: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. Design: Observational, cross-sectional study. Methods: Optical coherence tomography angiography (OCTA) images (4.5 × 4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA). Two concentric circles with 1.95-mm (inner) and 3.45-mm (outer) diameters were placed manually, producing an annulus of width 0.75 mm centered at the optic disc. PCD was calculated as the ratio of pixels associated with capillaries to the pixels in the annulus after large blood vessel removal. Continuous variables were assessed by analysis of variance and Tukey honest significant difference (HSD) test. Multiple linear regression analysis was performed to adjust for confounding factors. Results: Forty-three XFG eyes, 31 POAG eyes matched for visual field mean deviation, 33 XFS eyes, and 45 control eyes were analyzed. PCD demonstrated a progressive decrease from controls to XFS to POAG to XFG. Pairwise comparisons revealed significant differences in PCD between each pair of groups (all P < 0.01) except for PCD between XFS and POAG (P = 0.08). A multivariable model adjusting for age and stage showed a more significant decrease in PCD in XFG compared with POAG (P = 0.001). Conclusions: PCD was more significantly decreased in XFG compared with POAG eyes and in XFS compared with control eyes. OCTA provides the first quantitative evidence of the microvascular disturbance that accompanies XFS. 2018-09-05T04:35:57Z 2018-09-05T04:35:57Z 2018-03-01 Journal 21620989 2-s2.0-85046257567 10.22608/APO.2017318 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046257567&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/58984
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Yanin Suwan
Lawrence S. Geyman
Masoud Aghsaei Fard
Apichat Tantraworasin
Toco Y. Chui
Richard B. Rosen
Robert Ritch
Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
description Copyright © 2017 Asia-Pacific Academy of Ophthalmology. Unauthorized reproduction of this article is prohibited. Purpose: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. Design: Observational, cross-sectional study. Methods: Optical coherence tomography angiography (OCTA) images (4.5 × 4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA). Two concentric circles with 1.95-mm (inner) and 3.45-mm (outer) diameters were placed manually, producing an annulus of width 0.75 mm centered at the optic disc. PCD was calculated as the ratio of pixels associated with capillaries to the pixels in the annulus after large blood vessel removal. Continuous variables were assessed by analysis of variance and Tukey honest significant difference (HSD) test. Multiple linear regression analysis was performed to adjust for confounding factors. Results: Forty-three XFG eyes, 31 POAG eyes matched for visual field mean deviation, 33 XFS eyes, and 45 control eyes were analyzed. PCD demonstrated a progressive decrease from controls to XFS to POAG to XFG. Pairwise comparisons revealed significant differences in PCD between each pair of groups (all P < 0.01) except for PCD between XFS and POAG (P = 0.08). A multivariable model adjusting for age and stage showed a more significant decrease in PCD in XFG compared with POAG (P = 0.001). Conclusions: PCD was more significantly decreased in XFG compared with POAG eyes and in XFS compared with control eyes. OCTA provides the first quantitative evidence of the microvascular disturbance that accompanies XFS.
format Journal
author Yanin Suwan
Lawrence S. Geyman
Masoud Aghsaei Fard
Apichat Tantraworasin
Toco Y. Chui
Richard B. Rosen
Robert Ritch
author_facet Yanin Suwan
Lawrence S. Geyman
Masoud Aghsaei Fard
Apichat Tantraworasin
Toco Y. Chui
Richard B. Rosen
Robert Ritch
author_sort Yanin Suwan
title Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
title_short Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
title_full Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
title_fullStr Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
title_full_unstemmed Peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus POAG and healthy controls: An OCTA study
title_sort peripapillary perfused capillary density in exfoliation syndrome and exfoliation glaucoma versus poag and healthy controls: an octa study
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046257567&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58984
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