The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers

© 2018 Chuleegone Sornsuvit et al. The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation. An open-label, single-dose pharmacokinetic study was conducted. Twelve healthy volunteers were included in the study. After the volunteer...

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Main Authors: Chuleegone Sornsuvit, Darunee Hongwiset, Songwut Yotsawimonwat, Manatchaya Toonkum, Satawat Thongsawat, Wandee Taesotikul
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59028
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spelling th-cmuir.6653943832-590282018-09-05T04:36:34Z The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers Chuleegone Sornsuvit Darunee Hongwiset Songwut Yotsawimonwat Manatchaya Toonkum Satawat Thongsawat Wandee Taesotikul Medicine © 2018 Chuleegone Sornsuvit et al. The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation. An open-label, single-dose pharmacokinetic study was conducted. Twelve healthy volunteers were included in the study. After the volunteers had fasted overnight for 10 h, a single-dose generic silymarin 140 mg SMEDDS soft capsule was administered. Then 10 ml blood samples were taken at 0.0, 0.25, 0.50, 0.75, 1.0, 1.33, 1.67, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 h. The plasma silybin concentrations were analyzed using validated LC-MS/MS. The pharmacokinetic parameters were analyzed and calculated. The pharmacokinetic parameters were calculated after silymarin had been administered as a single capsule. The mean (range) Cmaxwas 812.43 (259.47-1505.47) ng/ml at 0.80 (0.25-1.67) h (tmax). The mean (range) AUC0-tand AUC0-infwere 658.80 (268.29-1045.01) ng.h/ml and 676.98 (274.10-1050.96) ng.h/ml, respectively. The mean keand t1/2were 0.5386 h-1and 1.91 h, respectively. The silymarin SMEDDS formulation soft capsule showed rapid absorption and high oral bioavailability. 2018-09-05T04:36:34Z 2018-09-05T04:36:34Z 2018-01-01 Journal 17414288 1741427X 2-s2.0-85051031069 10.1155/2018/1507834 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051031069&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59028
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Chuleegone Sornsuvit
Darunee Hongwiset
Songwut Yotsawimonwat
Manatchaya Toonkum
Satawat Thongsawat
Wandee Taesotikul
The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
description © 2018 Chuleegone Sornsuvit et al. The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation. An open-label, single-dose pharmacokinetic study was conducted. Twelve healthy volunteers were included in the study. After the volunteers had fasted overnight for 10 h, a single-dose generic silymarin 140 mg SMEDDS soft capsule was administered. Then 10 ml blood samples were taken at 0.0, 0.25, 0.50, 0.75, 1.0, 1.33, 1.67, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 h. The plasma silybin concentrations were analyzed using validated LC-MS/MS. The pharmacokinetic parameters were analyzed and calculated. The pharmacokinetic parameters were calculated after silymarin had been administered as a single capsule. The mean (range) Cmaxwas 812.43 (259.47-1505.47) ng/ml at 0.80 (0.25-1.67) h (tmax). The mean (range) AUC0-tand AUC0-infwere 658.80 (268.29-1045.01) ng.h/ml and 676.98 (274.10-1050.96) ng.h/ml, respectively. The mean keand t1/2were 0.5386 h-1and 1.91 h, respectively. The silymarin SMEDDS formulation soft capsule showed rapid absorption and high oral bioavailability.
format Journal
author Chuleegone Sornsuvit
Darunee Hongwiset
Songwut Yotsawimonwat
Manatchaya Toonkum
Satawat Thongsawat
Wandee Taesotikul
author_facet Chuleegone Sornsuvit
Darunee Hongwiset
Songwut Yotsawimonwat
Manatchaya Toonkum
Satawat Thongsawat
Wandee Taesotikul
author_sort Chuleegone Sornsuvit
title The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
title_short The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
title_full The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
title_fullStr The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
title_full_unstemmed The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
title_sort bioavailability and pharmacokinetics of silymarin smedds formulation study in healthy thai volunteers
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051031069&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59028
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