Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells
© 2018 Elsevier Masson SAS Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease (AD), invokes a cascade of oxidative damage to neurons and eventually leads to neuronal death. This study evaluated the protective effects of lutein extract from yellow cocoons of Bombyx mori, and its unde...
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th-cmuir.6653943832-590942018-09-05T04:37:59Z Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells Nongnuch Singhrang Chainarong Tocharus Sarinthorn Thummayot Manote Sutheerawattananonda Jiraporn Tocharus Pharmacology, Toxicology and Pharmaceutics © 2018 Elsevier Masson SAS Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease (AD), invokes a cascade of oxidative damage to neurons and eventually leads to neuronal death. This study evaluated the protective effects of lutein extract from yellow cocoons of Bombyx mori, and its underlying mechanisms against was investigated to assess its protective effects and the underlying mechanisms against Aβ25-35-induced neuronal cell death in cultured rat pheochromocytoma (PC12) cells. Aβ25-35-induced neuronal toxicity is characterized by decrease in cell viability, increase in intracellular reactive oxygen species (ROS) production, activation of mitochondrial death pathway, and activation the phospholyration of mitogen-activated protein kinase (MAPKs) pathway. Pretreatment with silk lutein extract significantly attenuated Aβ25-35-induced loss of cell viability, apoptosis, MAPKs pathway activation and ROS production. Taken together, our present study suggests that silk lutein extract protects PC12 cells from Aβ25-35-induced neurotoxicity via the reduction of the ROS production, and subsequent attenuation of the mitochondrial death pathway and reduces the activation of the MAPK kinase pathways. This compound might beneficial as potential therapeutic agent to prevent or retard the development and progression of AD. 2018-09-05T04:37:59Z 2018-09-05T04:37:59Z 2018-07-01 Journal 19506007 07533322 2-s2.0-85045876128 10.1016/j.biopha.2018.04.045 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045876128&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59094 |
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Pharmacology, Toxicology and Pharmaceutics Nongnuch Singhrang Chainarong Tocharus Sarinthorn Thummayot Manote Sutheerawattananonda Jiraporn Tocharus Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
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© 2018 Elsevier Masson SAS Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease (AD), invokes a cascade of oxidative damage to neurons and eventually leads to neuronal death. This study evaluated the protective effects of lutein extract from yellow cocoons of Bombyx mori, and its underlying mechanisms against was investigated to assess its protective effects and the underlying mechanisms against Aβ25-35-induced neuronal cell death in cultured rat pheochromocytoma (PC12) cells. Aβ25-35-induced neuronal toxicity is characterized by decrease in cell viability, increase in intracellular reactive oxygen species (ROS) production, activation of mitochondrial death pathway, and activation the phospholyration of mitogen-activated protein kinase (MAPKs) pathway. Pretreatment with silk lutein extract significantly attenuated Aβ25-35-induced loss of cell viability, apoptosis, MAPKs pathway activation and ROS production. Taken together, our present study suggests that silk lutein extract protects PC12 cells from Aβ25-35-induced neurotoxicity via the reduction of the ROS production, and subsequent attenuation of the mitochondrial death pathway and reduces the activation of the MAPK kinase pathways. This compound might beneficial as potential therapeutic agent to prevent or retard the development and progression of AD. |
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author |
Nongnuch Singhrang Chainarong Tocharus Sarinthorn Thummayot Manote Sutheerawattananonda Jiraporn Tocharus |
author_facet |
Nongnuch Singhrang Chainarong Tocharus Sarinthorn Thummayot Manote Sutheerawattananonda Jiraporn Tocharus |
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Nongnuch Singhrang |
title |
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
title_short |
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
title_full |
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
title_fullStr |
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
title_full_unstemmed |
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells |
title_sort |
protective effects of silk lutein extract from bombyx mori cocoons on β-amyloid peptide-induced apoptosis in pc12 cells |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045876128&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59094 |
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