O-methylbulbocapnine and dicentrine suppress LPS-induced inflammatory response by blocking NF-κB and AP-1 activation through inhibiting MAPKs and Akt signaling in RAW264.7 macrophages

• Main Authors: Supachai Yodkeeree, Chanatip Ooppachai, Wilart Pompimon, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052377360&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59106
• Institution: Chiang Mai University

© 2018 The Pharmaceutical Society of Japan. The natural aporphine alkaloids including crebanine (CN), O-methylbulbocapnine (OMP), and dicentrine (DC), and protoberberine alkaloids, tetrahydropalmatine (THP) and N-methyl tetrahydropalmatine (NTHP), have been found in Stephania venosa. Previous report...