Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities

© 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and...

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Main Authors:	Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan
Format:	Journal
Published:	2018
Subjects:	Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59108
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-591082018-09-05T04:38:24Z Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan Pharmacology, Toxicology and Pharmaceutics © 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy and mass spectrometry. Rhinacanthin S (1) exhibited acetylcholinesterase inhibition activity with a % inhibition value of 48.04 ± 3.25. The known rhinacanthin A (5) showed cytotoxicity against a MCF-7 cell line with an IC50value of 8.79 μM, while rhinacanthin N (15) was active against the NCI-H187 cell line with an IC50= 2.24 μM and Vero cells (IC50= 3.00 μM) 2018-09-05T04:38:24Z 2018-09-05T04:38:24Z 2018-01-01 Journal 18736971 0367326X 2-s2.0-85034591184 10.1016/j.fitote.2017.11.011 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59108
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Pharmacology, Toxicology and Pharmaceutics Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
description	© 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy and mass spectrometry. Rhinacanthin S (1) exhibited acetylcholinesterase inhibition activity with a % inhibition value of 48.04 ± 3.25. The known rhinacanthin A (5) showed cytotoxicity against a MCF-7 cell line with an IC50value of 8.79 μM, while rhinacanthin N (15) was active against the NCI-H187 cell line with an IC50= 2.24 μM and Vero cells (IC50= 3.00 μM)
format	Journal
author	Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan
author_facet	Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan
author_sort	Sirada Boonyaketgoson
title	Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_short	Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_full	Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_fullStr	Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_full_unstemmed	Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_sort	naphthoquinones from the leaves of rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59108
_version_	1681425190320340992

Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities

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