Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines

Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines

© 2018 The Author(s). Herein, a new molecular nanoparticle based on iron(III)-tannic complexes (Fe-TA NPs) is presented. The Fe-TA NPs were simply obtained by mixing the precursors in a buffered solution at room temperature, and they exhibited good physicochemical properties with capability of induc...

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Main Authors: Krungchanuchat Saowalak, Thongtem Titipun, Thongtem Somchai, Pilapong Chalermchai
Format: Journal
Published: 2018
Subjects:
Multidisciplinary
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046122443&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59184
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-591842018-09-05T04:41:11Z Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines Krungchanuchat Saowalak Thongtem Titipun Thongtem Somchai Pilapong Chalermchai Multidisciplinary © 2018 The Author(s). Herein, a new molecular nanoparticle based on iron(III)-tannic complexes (Fe-TA NPs) is presented. The Fe-TA NPs were simply obtained by mixing the precursors in a buffered solution at room temperature, and they exhibited good physicochemical properties with capability of inducing autophagy in both hepatocellular carcinoma cells (HepG2.2.15) and normal rat hepatocytes (AML12). The Fe-TA NPs were found to induce HepG2.2.15 cell death via autophagic cell death but have no effect on cell viability in AML12 cells. This is possibly due to the much higher uptake of the Fe-TA NPs by the HepG2.2.15 cells via the receptor-mediated endocytosis pathway. As a consequence, enhancement of the T1MRI contrast was clearly observed in the HepG2.2.15 cells. The results demonstrate that the Fe-TA NPs could provide a new strategy combining diagnostic and therapeutic functions for hepatocellular carcinoma. Additionally, because of their autophagy-inducing properties, they can be applied as autophagy enhancers for prevention and treatment of other diseases. 2018-09-05T04:41:11Z 2018-09-05T04:41:11Z 2018-12-01 Journal 20452322 2-s2.0-85046122443 10.1038/s41598-018-25108-1 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046122443&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59184
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Krungchanuchat Saowalak
Thongtem Titipun
Thongtem Somchai
Pilapong Chalermchai
Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
description © 2018 The Author(s). Herein, a new molecular nanoparticle based on iron(III)-tannic complexes (Fe-TA NPs) is presented. The Fe-TA NPs were simply obtained by mixing the precursors in a buffered solution at room temperature, and they exhibited good physicochemical properties with capability of inducing autophagy in both hepatocellular carcinoma cells (HepG2.2.15) and normal rat hepatocytes (AML12). The Fe-TA NPs were found to induce HepG2.2.15 cell death via autophagic cell death but have no effect on cell viability in AML12 cells. This is possibly due to the much higher uptake of the Fe-TA NPs by the HepG2.2.15 cells via the receptor-mediated endocytosis pathway. As a consequence, enhancement of the T1MRI contrast was clearly observed in the HepG2.2.15 cells. The results demonstrate that the Fe-TA NPs could provide a new strategy combining diagnostic and therapeutic functions for hepatocellular carcinoma. Additionally, because of their autophagy-inducing properties, they can be applied as autophagy enhancers for prevention and treatment of other diseases.
format Journal
author Krungchanuchat Saowalak
Thongtem Titipun
Thongtem Somchai
Pilapong Chalermchai
author_facet Krungchanuchat Saowalak
Thongtem Titipun
Thongtem Somchai
Pilapong Chalermchai
author_sort Krungchanuchat Saowalak
title Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
title_short Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
title_full Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
title_fullStr Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
title_full_unstemmed Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T<inf>1</inf>MRI Contrast in Liver Cell Lines
title_sort iron(iii)-tannic molecular nanoparticles enhance autophagy effect and t<inf>1</inf>mri contrast in liver cell lines
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046122443&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59184
_version_ 1681425204163641344

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