Designed zinc finger protein interacting with the HIV-1 integrase recognition sequence at 2-LTR-circle junctions

• Main Authors: Supachai Sakkhachornphop, Supat Jiranusornkul, Kanchanok Kodchakorn, Sawitree Nangola, Thira Sirisanthana, Chatchai Tayapiwatana
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70350511438&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59337
• Institution: Chiang Mai University

Integration of HIV-1 cDNA into the host genome is a crucial step for viral propagation. Two nucleotides, cytosine and adenine (CA), conserved at the 3′ end of the viral cDNA genome, are cleaved by the viral integrase (IN) enzyme. As IN plays a crucial role in the early stages of the HIV-1 life cycle...