Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220

Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C...

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Main Authors:	Masahiko Isaka, Urarat Srisanoh, Sukitaya Veeranondha, Wilunda Choowong, Saisamorn Lumyong
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349220966&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59339
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-59339
record_format	dspace
spelling	th-cmuir.6653943832-593392018-09-10T03:23:49Z Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220 Masahiko Isaka Urarat Srisanoh Sukitaya Veeranondha Wilunda Choowong Saisamorn Lumyong Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC50values of 1.1-7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC50of 3.1 and 2.8 μg/mL. © 2009 Elsevier Ltd. All rights reserved. 2018-09-10T03:14:02Z 2018-09-10T03:14:02Z 2009-10-24 Journal 00404020 2-s2.0-70349220966 10.1016/j.tet.2009.08.077 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349220966&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59339
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Masahiko Isaka Urarat Srisanoh Sukitaya Veeranondha Wilunda Choowong Saisamorn Lumyong Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
description	Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC50values of 1.1-7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC50of 3.1 and 2.8 μg/mL. © 2009 Elsevier Ltd. All rights reserved.
format	Journal
author	Masahiko Isaka Urarat Srisanoh Sukitaya Veeranondha Wilunda Choowong Saisamorn Lumyong
author_facet	Masahiko Isaka Urarat Srisanoh Sukitaya Veeranondha Wilunda Choowong Saisamorn Lumyong
author_sort	Masahiko Isaka
title	Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
title_short	Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
title_full	Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
title_fullStr	Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
title_full_unstemmed	Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
title_sort	cytotoxic eremophilane sesquiterpenoids from the saprobic fungus berkleasmium nigroapicale bcc 8220
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349220966&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59339
_version_	1681425232889380864

Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220

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