Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment

Acne vulgaris impairs the appearance of an individual and causes psychological irritation. Inflammatory acne lesion is caused by multifactor incorporates in each step of acne pathogenesis. In an attempt to archive inflammatory lesion treatment with the promise of prevention of acne vulgaris, randomi...

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Main Authors: C. Ruamrak, N. Lourith, S. Natakankitkul
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59397
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-593972018-09-10T03:24:03Z Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment C. Ruamrak N. Lourith S. Natakankitkul Biochemistry, Genetics and Molecular Biology Chemical Engineering Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Acne vulgaris impairs the appearance of an individual and causes psychological irritation. Inflammatory acne lesion is caused by multifactor incorporates in each step of acne pathogenesis. In an attempt to archive inflammatory lesion treatment with the promise of prevention of acne vulgaris, randomized and double-blind studies on the comparison of the efficacies of topical formulations containing 5% sodium ascorbyl phosphate (SAP) and 0.2% retinol, separately as well as in combination application, were conducted. The resulting data showed that SAP reduced the inflammatory lesion by 20.14% and 48.82% within 4 and 8 weeks respectively. Application of the formulation containing retinol slightly improved the treatment efficacy as the lesion reduced by 21.79% and 49.50% after 4 and 8 weeks respectively. The combination treatment significantly reduced the inflammatory lesion by 29.28% after 4 weeks and 63.10% after 8 weeks of application. The most effective treatment was by using the combination of 5% SAP and 0.2% retinol, which incorporated the synergistic effects on lipid peroxidation and sebaceous gland function in addition to the enhancement of SAP permeability by the desquamation of stratum corneum influenced by retinol, keratin plug removal and anti-inflammatory effect of retinol. This study promises for the development of cosmetic products to overcome aesthetic and psychological problems caused by acne vulgaris. © 2009 The Authors. 2018-09-10T03:14:43Z 2018-09-10T03:14:43Z 2009-02-01 Journal 14682494 01425463 2-s2.0-58149291737 10.1111/j.1468-2494.2008.00479.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149291737&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59397
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
C. Ruamrak
N. Lourith
S. Natakankitkul
Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
description Acne vulgaris impairs the appearance of an individual and causes psychological irritation. Inflammatory acne lesion is caused by multifactor incorporates in each step of acne pathogenesis. In an attempt to archive inflammatory lesion treatment with the promise of prevention of acne vulgaris, randomized and double-blind studies on the comparison of the efficacies of topical formulations containing 5% sodium ascorbyl phosphate (SAP) and 0.2% retinol, separately as well as in combination application, were conducted. The resulting data showed that SAP reduced the inflammatory lesion by 20.14% and 48.82% within 4 and 8 weeks respectively. Application of the formulation containing retinol slightly improved the treatment efficacy as the lesion reduced by 21.79% and 49.50% after 4 and 8 weeks respectively. The combination treatment significantly reduced the inflammatory lesion by 29.28% after 4 weeks and 63.10% after 8 weeks of application. The most effective treatment was by using the combination of 5% SAP and 0.2% retinol, which incorporated the synergistic effects on lipid peroxidation and sebaceous gland function in addition to the enhancement of SAP permeability by the desquamation of stratum corneum influenced by retinol, keratin plug removal and anti-inflammatory effect of retinol. This study promises for the development of cosmetic products to overcome aesthetic and psychological problems caused by acne vulgaris. © 2009 The Authors.
format Journal
author C. Ruamrak
N. Lourith
S. Natakankitkul
author_facet C. Ruamrak
N. Lourith
S. Natakankitkul
author_sort C. Ruamrak
title Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
title_short Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
title_full Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
title_fullStr Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
title_full_unstemmed Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
title_sort comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149291737&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59397
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