Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations

Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of...

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Main Authors: Parinya Panuwet, Tippawan Prapamontol, Somporn Chantara, Prasak Thavornyuthikarn, Roberto Bravo, Paula Restrepo, Robert D. Walker, Bryan L. Williams, Larry L. Needham, Dana B. Barr
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59603
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spelling th-cmuir.6653943832-596032018-09-10T03:24:01Z Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations Parinya Panuwet Tippawan Prapamontol Somporn Chantara Prasak Thavornyuthikarn Roberto Bravo Paula Restrepo Robert D. Walker Bryan L. Williams Larry L. Needham Dana B. Barr Environmental Science Pharmacology, Toxicology and Pharmaceutics Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of methyl parathion in urine samples collected from 136 farmers (age 20 to 65 years) and 306 school children (age 10 to 15 years) in 2006. Participants came from two topographically different areas: one was colder and mountainous, whereas the other was alluvial with climate fluctuations depending on the monsoon season. Both children and farmers were recruited from each area. Despite methyl parathion's prohibited use in agriculture in 2004, we detected PNP in >90% of all samples analyzed. We applied a nonparametric correlation test (PNP vs. DMP and DMTP) to determine whether the PNP found in most of the samples tested resulted from exposures to methyl parathion. DMP (Spearman's rho = 0.601 [p = 0.001] for farmers and Spearman's rho = 0.263 [p <0.001] for children) and DMTP (Spearman's rho = 0.296 [p = 0.003] for farmers and Spearman's rho = 0.304 [p<0.001] for children) were positively correlated with PNP, suggesting a common source for the three analytes, presumably methyl parathion or related environmental degradates. Although we found a modest correlation between the metabolites, our findings suggest that despite the prohibition, at least a portion (approximately 25% to 60%) of the PNP detected among farmers and children in Thailand may be attributed to exposure from continued methyl parathion use. © 2009 Springer Science+Business Media, LLC. 2018-09-10T03:18:10Z 2018-09-10T03:18:10Z 2009-04-14 Journal 00904341 2-s2.0-70349591122 10.1007/s00244-009-9315-x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349591122&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59603
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Environmental Science
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Environmental Science
Pharmacology, Toxicology and Pharmaceutics
Parinya Panuwet
Tippawan Prapamontol
Somporn Chantara
Prasak Thavornyuthikarn
Roberto Bravo
Paula Restrepo
Robert D. Walker
Bryan L. Williams
Larry L. Needham
Dana B. Barr
Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
description Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of methyl parathion in urine samples collected from 136 farmers (age 20 to 65 years) and 306 school children (age 10 to 15 years) in 2006. Participants came from two topographically different areas: one was colder and mountainous, whereas the other was alluvial with climate fluctuations depending on the monsoon season. Both children and farmers were recruited from each area. Despite methyl parathion's prohibited use in agriculture in 2004, we detected PNP in >90% of all samples analyzed. We applied a nonparametric correlation test (PNP vs. DMP and DMTP) to determine whether the PNP found in most of the samples tested resulted from exposures to methyl parathion. DMP (Spearman's rho = 0.601 [p = 0.001] for farmers and Spearman's rho = 0.263 [p <0.001] for children) and DMTP (Spearman's rho = 0.296 [p = 0.003] for farmers and Spearman's rho = 0.304 [p<0.001] for children) were positively correlated with PNP, suggesting a common source for the three analytes, presumably methyl parathion or related environmental degradates. Although we found a modest correlation between the metabolites, our findings suggest that despite the prohibition, at least a portion (approximately 25% to 60%) of the PNP detected among farmers and children in Thailand may be attributed to exposure from continued methyl parathion use. © 2009 Springer Science+Business Media, LLC.
format Journal
author Parinya Panuwet
Tippawan Prapamontol
Somporn Chantara
Prasak Thavornyuthikarn
Roberto Bravo
Paula Restrepo
Robert D. Walker
Bryan L. Williams
Larry L. Needham
Dana B. Barr
author_facet Parinya Panuwet
Tippawan Prapamontol
Somporn Chantara
Prasak Thavornyuthikarn
Roberto Bravo
Paula Restrepo
Robert D. Walker
Bryan L. Williams
Larry L. Needham
Dana B. Barr
author_sort Parinya Panuwet
title Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
title_short Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
title_full Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
title_fullStr Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
title_full_unstemmed Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
title_sort urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349591122&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59603
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