Reciprocal recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope by CD8⁺ T cells and NK cells

• Main Authors: Hathairat Thananchai, Tariro Makadzange, Katsumi Maenaka, Kimiko Kuroki, Yanchun Peng, Chris Conlon, Sarah Rowland-Jones, Tao Dong
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58849087061&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59644
• Institution: Chiang Mai University

Objectives: The HIV-1 Nef protein selectively downregulates human leukocyte antigen (HLA)-A and HLA-B but not HLA-C molecules on the surface of infected cells. This allows HIV-infected cells to evade recognition by most cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. We investigated th...