Breast cancer in the elderly: A histological assessment

Aims: To understand the correlation between the expression status of different biological markers in breast cancers in the elderly. Methods and results: Three hundred and ninety-seven cases were evaluated for expression of hormone receptors [oestrogen receptors (ER) α and β, progesterone receptor (P...

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Main Authors: Gary M. Tse, Puay Hoon Tan, Kin Mang Lau, Victor Piana De Andrade, Philip C.W. Lui, Joaquim S. Vong, Benjaporn Chaiwun, Christopher C. Lam, Alex M. Yu, Takuya Moriya
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59793
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-597932018-09-10T03:21:35Z Breast cancer in the elderly: A histological assessment Gary M. Tse Puay Hoon Tan Kin Mang Lau Victor Piana De Andrade Philip C.W. Lui Joaquim S. Vong Benjaporn Chaiwun Christopher C. Lam Alex M. Yu Takuya Moriya Medicine Aims: To understand the correlation between the expression status of different biological markers in breast cancers in the elderly. Methods and results: Three hundred and ninety-seven cases were evaluated for expression of hormone receptors [oestrogen receptors (ER) α and β, progesterone receptor (PR)], basal markers [p63, cytokeratin (CK) 5/6 and CK14] and others (HER2/neu, synaptophysin and chromogranin). The expression rates were 60, 29, 25, 6, 14, 8, 28, 17 and 5%, respectively, for these markers. The expression of ER α and β, PR, synaptophysin and chromogranin at any level correlated with low nuclear or tumour grades, whereas the expression of HER2/neu, CK5/6 and CK14 at any level correlated with high nuclear grade. By using hierarchical clustering, groups of HER2, luminal and basal types were identified. In addition, a neuroendocrine group was also identified, being characterized by expression of synaptophysin, chromogranin, ER and PR, but not HER2/neu, and other basal cytokeratins. This group was associated with lower nuclear grade, and hence better prognosis. Conclusions: Breast cancer in the elderly shows similar molecular groupings as other breast cancers, with an additional neuroendocrine group that is associated with a favourable biological marker profile. © 2009 Blackwell Publishing Limited. 2018-09-10T03:21:35Z 2018-09-10T03:21:35Z 2009-10-01 Journal 13652559 03090167 2-s2.0-70349921325 10.1111/j.1365-2559.2009.03400.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349921325&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59793
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Gary M. Tse
Puay Hoon Tan
Kin Mang Lau
Victor Piana De Andrade
Philip C.W. Lui
Joaquim S. Vong
Benjaporn Chaiwun
Christopher C. Lam
Alex M. Yu
Takuya Moriya
Breast cancer in the elderly: A histological assessment
description Aims: To understand the correlation between the expression status of different biological markers in breast cancers in the elderly. Methods and results: Three hundred and ninety-seven cases were evaluated for expression of hormone receptors [oestrogen receptors (ER) α and β, progesterone receptor (PR)], basal markers [p63, cytokeratin (CK) 5/6 and CK14] and others (HER2/neu, synaptophysin and chromogranin). The expression rates were 60, 29, 25, 6, 14, 8, 28, 17 and 5%, respectively, for these markers. The expression of ER α and β, PR, synaptophysin and chromogranin at any level correlated with low nuclear or tumour grades, whereas the expression of HER2/neu, CK5/6 and CK14 at any level correlated with high nuclear grade. By using hierarchical clustering, groups of HER2, luminal and basal types were identified. In addition, a neuroendocrine group was also identified, being characterized by expression of synaptophysin, chromogranin, ER and PR, but not HER2/neu, and other basal cytokeratins. This group was associated with lower nuclear grade, and hence better prognosis. Conclusions: Breast cancer in the elderly shows similar molecular groupings as other breast cancers, with an additional neuroendocrine group that is associated with a favourable biological marker profile. © 2009 Blackwell Publishing Limited.
format Journal
author Gary M. Tse
Puay Hoon Tan
Kin Mang Lau
Victor Piana De Andrade
Philip C.W. Lui
Joaquim S. Vong
Benjaporn Chaiwun
Christopher C. Lam
Alex M. Yu
Takuya Moriya
author_facet Gary M. Tse
Puay Hoon Tan
Kin Mang Lau
Victor Piana De Andrade
Philip C.W. Lui
Joaquim S. Vong
Benjaporn Chaiwun
Christopher C. Lam
Alex M. Yu
Takuya Moriya
author_sort Gary M. Tse
title Breast cancer in the elderly: A histological assessment
title_short Breast cancer in the elderly: A histological assessment
title_full Breast cancer in the elderly: A histological assessment
title_fullStr Breast cancer in the elderly: A histological assessment
title_full_unstemmed Breast cancer in the elderly: A histological assessment
title_sort breast cancer in the elderly: a histological assessment
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349921325&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59793
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