Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand

Background: Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infected children receiving HAART. Methods: Insulin resistance was assessed a...

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Main Authors: B. Lee, L. Aurpibul, V. Sirisanthana, A. Mangklabruks, T. Sirisanthana, Thanyawee Puthanakit
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59807
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spelling th-cmuir.6653943832-598072018-09-10T03:21:45Z Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand B. Lee L. Aurpibul V. Sirisanthana A. Mangklabruks T. Sirisanthana Thanyawee Puthanakit Medicine Background: Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infected children receiving HAART. Methods: Insulin resistance was assessed at 96 weeks of treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz with stavudine and lamivudine) among children in Chiang Mai, Thailand. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) ≥ 3.16, fasting c-peptide ≥ 4.40ng/mL or fasting insulin ≥ 25.0μU/mL. Impaired fasting glucose (IFG) was defined as glucose ≥110mg/dL. Measurements were analysed for associations with age, lipodystrophy, treatment regimen and clinical data. Results: The prevalence of insulin resistance was 6.5% no child had IFG. Those with insulin resistance were older with higher body mass index. Children ≥ 10 years had higher HOMA-IR, c-peptide and insulin, but no difference was seen in the frequency of insulin resistance. No associations between insulin resistance and lipodystrophy or treatment regimen were detected. Conclusions: Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy. © 2009 British HIV Association. 2018-09-10T03:21:45Z 2018-09-10T03:21:45Z 2009-08-24 Journal 14681293 14642662 2-s2.0-68949102262 10.1111/j.1468-1293.2008.00653.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68949102262&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59807
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
B. Lee
L. Aurpibul
V. Sirisanthana
A. Mangklabruks
T. Sirisanthana
Thanyawee Puthanakit
Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
description Background: Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infected children receiving HAART. Methods: Insulin resistance was assessed at 96 weeks of treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz with stavudine and lamivudine) among children in Chiang Mai, Thailand. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) ≥ 3.16, fasting c-peptide ≥ 4.40ng/mL or fasting insulin ≥ 25.0μU/mL. Impaired fasting glucose (IFG) was defined as glucose ≥110mg/dL. Measurements were analysed for associations with age, lipodystrophy, treatment regimen and clinical data. Results: The prevalence of insulin resistance was 6.5% no child had IFG. Those with insulin resistance were older with higher body mass index. Children ≥ 10 years had higher HOMA-IR, c-peptide and insulin, but no difference was seen in the frequency of insulin resistance. No associations between insulin resistance and lipodystrophy or treatment regimen were detected. Conclusions: Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy. © 2009 British HIV Association.
format Journal
author B. Lee
L. Aurpibul
V. Sirisanthana
A. Mangklabruks
T. Sirisanthana
Thanyawee Puthanakit
author_facet B. Lee
L. Aurpibul
V. Sirisanthana
A. Mangklabruks
T. Sirisanthana
Thanyawee Puthanakit
author_sort B. Lee
title Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
title_short Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
title_full Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
title_fullStr Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
title_full_unstemmed Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand
title_sort low prevalence of insulin resistance among hiv-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68949102262&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59807
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