Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women

Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women

Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the...

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Bibliographic Details
Main Authors: Tim R. Cressey, Russell Van Dyke, Gonzague Jourdain, Thanyawee Puthanakit, Anuvat Roongpisuthipong, Jullapong Achalapong, Prapap Yuthavisuthi, Sinart Prommas, Nantasak Chotivanich, Robert Maupin, Elizabeth Smith, David E. Shapiro, Mark Mirochnick
Format: Journal
Published: 2018
Subjects:
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66149098490&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59849
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Institution: Chiang Mai University
Description
Summary:Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) μg·h/ml, 11.2 (8.0 to 17.5) μg/ml, and 4.6 (1.7 to 12.5) μg/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

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