Association of low CD4 cell count and intrauterine growth retardation in Thailand
Objective: Each year, intrauterine growth retardation (IUGR) affects 20-30 million neonates worldwide, mostly in resource-limited settings. Increased perinatal and infant mortality has been associated with IUGR. Some studies have suggested that HIV infection could increase the risk of IUGR. To confi...
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th-cmuir.6653943832-598572018-09-10T03:22:35Z Association of low CD4 cell count and intrauterine growth retardation in Thailand Johann Cailhol Gonzague Jourdain Sophie Le Coeur Patrinee Traisathit Kamol Boonrod Sinart Prommas Chaiwat Putiyanun Annop Kanjanasing Marc Lallemant Medicine Objective: Each year, intrauterine growth retardation (IUGR) affects 20-30 million neonates worldwide, mostly in resource-limited settings. Increased perinatal and infant mortality has been associated with IUGR. Some studies have suggested that HIV infection could increase the risk of IUGR. To confirm this hypothesis, we examined the association between HIV-related factors and the risk of IUGR in Thailand. Patients and Methods: Data from a cohort of 1436 HIV-infected pregnant women enrolled in the "Perinatal HIV Prevention Trial-1", a clinical trial conducted from 1997 to 1999 in Thailand, were analyzed using a logistic regression, adjusting for risk factors usually associated with IUGR. Results: The rate of IUGR was 7.6%. Adjusting for a short maternal height, low body mass index, small weight gain during pregnancy, and infant female sex, a low maternal CD4 percentage was independently associated with IUGR (odds ratio 0.96, per 1% increment, 95% confidence interval 0.93 to 0.99, P = 0.03). Conclusions: The current World Health Organization recommendation to initiate combination antiretroviral therapy for immunocompromised women as early as possible during pregnancy for their own health and for the prevention of HIV mother-to-child transmission is likely to also decrease the incidence of IUGR. Encouraging immunocompromised HIV-infected women who plan to become pregnant to wait until immune restoration has been achieved may help to reduce the risk of IUGR. Copyright © 2009 by Lippincott Williams & Wilkins. 2018-09-10T03:22:35Z 2018-09-10T03:22:35Z 2009-04-01 Journal 15254135 2-s2.0-64249155675 10.1097/QAI.0b013e3181958560 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=64249155675&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59857 |
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Medicine Johann Cailhol Gonzague Jourdain Sophie Le Coeur Patrinee Traisathit Kamol Boonrod Sinart Prommas Chaiwat Putiyanun Annop Kanjanasing Marc Lallemant Association of low CD4 cell count and intrauterine growth retardation in Thailand |
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Objective: Each year, intrauterine growth retardation (IUGR) affects 20-30 million neonates worldwide, mostly in resource-limited settings. Increased perinatal and infant mortality has been associated with IUGR. Some studies have suggested that HIV infection could increase the risk of IUGR. To confirm this hypothesis, we examined the association between HIV-related factors and the risk of IUGR in Thailand. Patients and Methods: Data from a cohort of 1436 HIV-infected pregnant women enrolled in the "Perinatal HIV Prevention Trial-1", a clinical trial conducted from 1997 to 1999 in Thailand, were analyzed using a logistic regression, adjusting for risk factors usually associated with IUGR. Results: The rate of IUGR was 7.6%. Adjusting for a short maternal height, low body mass index, small weight gain during pregnancy, and infant female sex, a low maternal CD4 percentage was independently associated with IUGR (odds ratio 0.96, per 1% increment, 95% confidence interval 0.93 to 0.99, P = 0.03). Conclusions: The current World Health Organization recommendation to initiate combination antiretroviral therapy for immunocompromised women as early as possible during pregnancy for their own health and for the prevention of HIV mother-to-child transmission is likely to also decrease the incidence of IUGR. Encouraging immunocompromised HIV-infected women who plan to become pregnant to wait until immune restoration has been achieved may help to reduce the risk of IUGR. Copyright © 2009 by Lippincott Williams & Wilkins. |
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Journal |
author |
Johann Cailhol Gonzague Jourdain Sophie Le Coeur Patrinee Traisathit Kamol Boonrod Sinart Prommas Chaiwat Putiyanun Annop Kanjanasing Marc Lallemant |
author_facet |
Johann Cailhol Gonzague Jourdain Sophie Le Coeur Patrinee Traisathit Kamol Boonrod Sinart Prommas Chaiwat Putiyanun Annop Kanjanasing Marc Lallemant |
author_sort |
Johann Cailhol |
title |
Association of low CD4 cell count and intrauterine growth retardation in Thailand |
title_short |
Association of low CD4 cell count and intrauterine growth retardation in Thailand |
title_full |
Association of low CD4 cell count and intrauterine growth retardation in Thailand |
title_fullStr |
Association of low CD4 cell count and intrauterine growth retardation in Thailand |
title_full_unstemmed |
Association of low CD4 cell count and intrauterine growth retardation in Thailand |
title_sort |
association of low cd4 cell count and intrauterine growth retardation in thailand |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=64249155675&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59857 |
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