Mapping human genetic diversity in Asia

• Main Authors: Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, Amit Chaurasia, Chien Hsiun Chen, Jieming Chen, Yuan Tsong Chen, Jiayou Chu, Eva Maria C. Cutiongco-de La Paz, Maria Corazon A. De Ungria, Frederick C. Delfin, Juli Edo, Suthat Fuchareon, Ho Ghang, Takashi Gojobori, Junsong Han, Sheng Feng Ho, Boon Peng Hoh, Wei Huang, Hidetoshi Inoko, Pankaj Jha, Timothy A. Jinam, Li Jin, Jongsun Jung, Daoroong Kangwanpong, Jatupol Kampuansai, Giulia C. Kennedy, Preeti Khurana, Hyung Lae Kim, Kwangjoong Kim, Sangsoo Kim, Woo Yeon Kim, Kuchan Kimm, Ryosuke Kimura, Tomohiro Koike, Supasak Kulawonganunchai, Vikrant Kumar, Poh San Lai, Jong Young Lee, Sunghoon Lee, Edison T. Liu, Partha P. Majumder, Kiran Kumar Mandapati, Sangkot Marzuki, Wayne Mitchell, Mitali Mukerji, Kenji Naritomi, Chumpol Ngamphiw, Norio Niikawa, Nao Nishida, Bermseok Oh, Sangho Oh, Jun Ohashi, Akira Oka, Rick Ong, Carmencita D. Padilla, Prasit Palittapongarnpim, Henry B. Perdigon, Maude Elvira Phipps, Eileen Png, Yoshiyuki Sakaki, Jazelyn M. Salvador, Yuliana Sandraling, Vinod Scaria, Mark Seielstad, Mohd Ros Sidek, Amit Sinha, Metawee Srikummool, Herawati Sudoyo, Sumio Sugano, Helena Suryadi, Yoshiyuki Suzuki, Kristina A. Tabbada, Adrian Tan, Katsushi Tokunaga, Sissades Tongsima, Lilian P. Villamor, Eric Wang, Ying Wang, Haifeng Wang, Jer Yuarn Wu, Huasheng Xiao, Shuhua Xu, Jin Ok Yang, Yin Yao Shugart, Hyang Sook Yoo, Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil
• Format: Journal
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=72149083621&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59971
• Institution: Chiang Mai University

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.