Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital

The characteristics of preventable adverse drug reaction (pADR) in hospitalized patients in Phrae Hospital were identified by a retrospective descriptive analysis. All ADR report forms of patient during fiscal year 2003 were explored. From 189 reports, 188 ADR reports were analyzed. Sixty-eight case...

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Main Authors: Kannika Thiankhanithikun, Sayam Kaewvichit
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60003
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spelling th-cmuir.6653943832-600032018-09-10T03:26:20Z Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital Kannika Thiankhanithikun Sayam Kaewvichit Multidisciplinary The characteristics of preventable adverse drug reaction (pADR) in hospitalized patients in Phrae Hospital were identified by a retrospective descriptive analysis. All ADR report forms of patient during fiscal year 2003 were explored. From 189 reports, 188 ADR reports were analyzed. Sixty-eight cases (36.17%) were classified with Schumock and Thornton criteria as pADR. Mean age of pADR patient was 42.97 years. Female was of the same number as male. Top- three underlying diseases were chronic renal failure, HIV and hypertension. Eight pADR (11.76%) were related to hospital admission and mostly (80.88%) considered non-serious ADR. Nine cases (13.24%) were considered severe to initial or prolonged hospitalization and required life-threatening management. The relationship of pADR to drug exposure was determined to be probable. Half of them occurred in skin and appendage system and body as a whole-general disorders system organ class of WHO. Most outcome (91.18%) was recovered without sequelae. "Antibiotics", "contrast media" and "miscellaneous" were top-three classes of drugs causing pADR. The third high-priority pADR code which accounted for 90% of all reports were (1) required therapeutic drug monitoring or other necessary laboratory tests were not performed or not performed frequently enough criteria (45.95%), (2) dose, route or frequency of administration was not appropriate for the patient's age, weight or disease criteria (24.32%), and (3) drugs involved were not appropriate for the patient's clinical condition criteria (19.82%). The data from this study reflected the importance and urgency for better understanding of pADRs in Thai-hospitalized patients and suggestion of the better interventions or model to prevent patients suffering from ADRs. Further nationwide studies are needed to determine ADR-associated factors and to develop strategies for prevention of pADR in hospitalized patients. 2018-09-10T03:26:20Z 2018-09-10T03:26:20Z 2009-01-01 Journal 16851994 2-s2.0-70350055476 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70350055476&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60003
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Kannika Thiankhanithikun
Sayam Kaewvichit
Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
description The characteristics of preventable adverse drug reaction (pADR) in hospitalized patients in Phrae Hospital were identified by a retrospective descriptive analysis. All ADR report forms of patient during fiscal year 2003 were explored. From 189 reports, 188 ADR reports were analyzed. Sixty-eight cases (36.17%) were classified with Schumock and Thornton criteria as pADR. Mean age of pADR patient was 42.97 years. Female was of the same number as male. Top- three underlying diseases were chronic renal failure, HIV and hypertension. Eight pADR (11.76%) were related to hospital admission and mostly (80.88%) considered non-serious ADR. Nine cases (13.24%) were considered severe to initial or prolonged hospitalization and required life-threatening management. The relationship of pADR to drug exposure was determined to be probable. Half of them occurred in skin and appendage system and body as a whole-general disorders system organ class of WHO. Most outcome (91.18%) was recovered without sequelae. "Antibiotics", "contrast media" and "miscellaneous" were top-three classes of drugs causing pADR. The third high-priority pADR code which accounted for 90% of all reports were (1) required therapeutic drug monitoring or other necessary laboratory tests were not performed or not performed frequently enough criteria (45.95%), (2) dose, route or frequency of administration was not appropriate for the patient's age, weight or disease criteria (24.32%), and (3) drugs involved were not appropriate for the patient's clinical condition criteria (19.82%). The data from this study reflected the importance and urgency for better understanding of pADRs in Thai-hospitalized patients and suggestion of the better interventions or model to prevent patients suffering from ADRs. Further nationwide studies are needed to determine ADR-associated factors and to develop strategies for prevention of pADR in hospitalized patients.
format Journal
author Kannika Thiankhanithikun
Sayam Kaewvichit
author_facet Kannika Thiankhanithikun
Sayam Kaewvichit
author_sort Kannika Thiankhanithikun
title Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
title_short Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
title_full Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
title_fullStr Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
title_full_unstemmed Determination of incidence and characteristics of preventable adverse drug reactions: A study in Phrae Hospital
title_sort determination of incidence and characteristics of preventable adverse drug reactions: a study in phrae hospital
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70350055476&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60003
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