Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

• Main Authors: Yih Shyan Lin, Rudeewan Tungpradit, Supachok Sinchaikul, Feng Ming An, Der Zen Liu, Suree Phutrakul, Shui Tein Chen
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=57349142938&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60133
• Institution: Chiang Mai University

This report describes the synthesis of four novel paclitaxel based prodrugs with glycan conjugation (1-4). Glycans were conjugated using an ester or ether bond as the linker between 2′-paclitaxel and the 2′-glucose or glucuronic acid moiety. These prodrugs showed good water solubility and selective...