Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines

• Main Authors: Songyot Anuchapreeda, Singkome Tima, Chadarat Duangrat, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47549084273&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60146
• Institution: Chiang Mai University

Purpose: Leukemias are groups of hematological malignancies with high incidence and mortality rates in patients worldwide. There have been shown in many studies that Wilms' tumor1 (WT1) gene were highly expressed in leukemic blast cells. Curcuminoids, major active components of the spice turmer...