Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

• Main Authors: Arintaya Phrommintikul, Lavinia Tran, Andrew Kompa, Bing Wang, Anastasia Adrahtas, Danielle Cantwell, Darren J. Kelly, Henry Krum
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=41749089597&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60176
• Institution: Chiang Mai University

The RhoA-Rho kinase (ROCK) signaling pathway has an important role in cardiovascular diseases. However, the effect of Rho kinase inhibition on pressure overload-induced cardiac hypertrophy (POH) and associated diastolic dysfunction has not been evaluated. This study examined the effect of a selectiv...