Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells

Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells

Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in...

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Main Authors: Ratana Banjerdpongchai, Kittiphan Suwannachot, Viboon Rattanapanone, Bungorn Sripanidkulchai
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66149086198&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60205
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-602052018-09-10T03:47:21Z Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells Ratana Banjerdpongchai Kittiphan Suwannachot Viboon Rattanapanone Bungorn Sripanidkulchai Biochemistry, Genetics and Molecular Biology Medicine Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in vitro. The extract suppressed HL-60 cell growth and decreased cell viability in a dose- and time-dependent manner. Apoptotic cell death was demonstrated by changes in cell morphology, externalization of phosphatidylserine on the cell surface, loss in mitochondrial transmembrane potential and activation of caspase 3. Apoptosis induced by K. parviflora Wall. ex. Baker rhizome ethanolic extract was enhanced by treatment with paclitaxel or doxorubicin, and inhibitors of Akt, PI3-K and MEK. 2018-09-10T03:39:19Z 2018-09-10T03:39:19Z 2008-01-01 Journal 2476762X 15137368 2-s2.0-66149086198 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66149086198&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60205
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Ratana Banjerdpongchai
Kittiphan Suwannachot
Viboon Rattanapanone
Bungorn Sripanidkulchai
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
description Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in vitro. The extract suppressed HL-60 cell growth and decreased cell viability in a dose- and time-dependent manner. Apoptotic cell death was demonstrated by changes in cell morphology, externalization of phosphatidylserine on the cell surface, loss in mitochondrial transmembrane potential and activation of caspase 3. Apoptosis induced by K. parviflora Wall. ex. Baker rhizome ethanolic extract was enhanced by treatment with paclitaxel or doxorubicin, and inhibitors of Akt, PI3-K and MEK.
format Journal
author Ratana Banjerdpongchai
Kittiphan Suwannachot
Viboon Rattanapanone
Bungorn Sripanidkulchai
author_facet Ratana Banjerdpongchai
Kittiphan Suwannachot
Viboon Rattanapanone
Bungorn Sripanidkulchai
author_sort Ratana Banjerdpongchai
title Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
title_short Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
title_full Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
title_fullStr Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
title_full_unstemmed Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
title_sort ethanolic rhizome extract from kaempferia parviflora wall. ex. baker induces apoptosis in hl-60 cells
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66149086198&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60205
_version_ 1681425392918855680

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