Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand

Salmonella enterica isolates from poultry (n=125) and swine (n=132) in Thailand were investigated for antibiotic resistance, susceptibility to disinfectants (benzalkonium chloride (BKC), chlorhexidine digluconate (CHX), zinc chloride and copper sulfate) and cyclohexane tolerance. Forty-two percent w...

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Main Authors: Rungtip Chuanchuen, Pornpen Pathanasophon, Sirintip Khemtong, Wechsiri Wannaprasat, Pawin Padungtod
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60216
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-602162018-09-10T03:49:20Z Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand Rungtip Chuanchuen Pornpen Pathanasophon Sirintip Khemtong Wechsiri Wannaprasat Pawin Padungtod Business, Management and Accounting Veterinary Salmonella enterica isolates from poultry (n=125) and swine (n=132) in Thailand were investigated for antibiotic resistance, susceptibility to disinfectants (benzalkonium chloride (BKC), chlorhexidine digluconate (CHX), zinc chloride and copper sulfate) and cyclohexane tolerance. Forty-two percent were of multiple resistance to antibiotics. The minimum inhibitory concentrations (MICs) of all antibiotics against isolates from swine were higher than that against the isolates from poultry. There were generally few variations in MICs to all disinfectants, indicating that the isolates had either no or only a limited degree of developed resistance to the disinfectants tested. Only 5 isolates (1.9%) were tolerant to cyclohexane. The proton-dependent efflux systems did not play a major role in the reduced susceptibility to BKC and CHX, since susceptibility was not restored when an efflux inhibitor, carbonyl cyanide m-chlorophenylhydrazone (CCCP) was present. Successive exposure to subinhibitory concentrations of BKC and CHX generated mutants resistant to BKC and CHX. A spontaneous BKC-resistant derivative expressed cross-resistance to antibiotics, chloramphenicol and erythromycin. The mechanism responsible for cross-resistance between BKC and antibiotics was not driven by the proton motif force (PMF). 2018-09-10T03:39:27Z 2018-09-10T03:39:27Z 2008-06-01 Journal 13477439 09167250 2-s2.0-47549100895 10.1292/jvms.70.595 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47549100895&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60216
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Business, Management and Accounting
Veterinary
spellingShingle Business, Management and Accounting
Veterinary
Rungtip Chuanchuen
Pornpen Pathanasophon
Sirintip Khemtong
Wechsiri Wannaprasat
Pawin Padungtod
Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
description Salmonella enterica isolates from poultry (n=125) and swine (n=132) in Thailand were investigated for antibiotic resistance, susceptibility to disinfectants (benzalkonium chloride (BKC), chlorhexidine digluconate (CHX), zinc chloride and copper sulfate) and cyclohexane tolerance. Forty-two percent were of multiple resistance to antibiotics. The minimum inhibitory concentrations (MICs) of all antibiotics against isolates from swine were higher than that against the isolates from poultry. There were generally few variations in MICs to all disinfectants, indicating that the isolates had either no or only a limited degree of developed resistance to the disinfectants tested. Only 5 isolates (1.9%) were tolerant to cyclohexane. The proton-dependent efflux systems did not play a major role in the reduced susceptibility to BKC and CHX, since susceptibility was not restored when an efflux inhibitor, carbonyl cyanide m-chlorophenylhydrazone (CCCP) was present. Successive exposure to subinhibitory concentrations of BKC and CHX generated mutants resistant to BKC and CHX. A spontaneous BKC-resistant derivative expressed cross-resistance to antibiotics, chloramphenicol and erythromycin. The mechanism responsible for cross-resistance between BKC and antibiotics was not driven by the proton motif force (PMF).
format Journal
author Rungtip Chuanchuen
Pornpen Pathanasophon
Sirintip Khemtong
Wechsiri Wannaprasat
Pawin Padungtod
author_facet Rungtip Chuanchuen
Pornpen Pathanasophon
Sirintip Khemtong
Wechsiri Wannaprasat
Pawin Padungtod
author_sort Rungtip Chuanchuen
title Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
title_short Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
title_full Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
title_fullStr Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
title_full_unstemmed Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
title_sort susceptibilities to antimicrobials and disinfectants in salmonella isolates obtained from poultry and swine in thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47549100895&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60216
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