Fed-batch optimization of recombinant α-amylase production by Bacillus subtilis using a modified Markov Chain monte carlo technique

• Main Authors: Wanwisa Skolpap, Somboon Nuchprayoon, Jeno M. Scharer, Nurak Grisdanurak, Peter L. Douglas, Murray Moo-Young
• 格式: 雜誌
• 出版: 2018
• 主題: Chemical Engineering; Chemistry
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52349110872&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60223

A modified Markov Chain Monte Carlo (MCMC) searching procedure was developed to search for an optimal set of decision variables and optimal feed rate trajectories for recombinant α-amylase expression by Bacillus subtilis ATCC 6051a. The bacterium also synthesizes proteases as undesirable products in...