Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis

Aim: To determine the levels of chondroitin sulphate (CS) WF6 epitope, recognized by WF6 monoclonal antibody, in gingival crevicular fluid (GCF) from different stages of periodontal disease and healthy periodontium, and to correlate those levels with clinical parameters. Material and Methods: GCF sa...

Full description

Saved in:
Bibliographic Details
Main Authors: Sakornrat Khongkhunthian, Napachakorn Srimueang, Suttichai Krisanaprakornkit, Komkham Pattanaporn, Siriwan Ong-Chai, Prachya Kongtawelert
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=51749107033&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60306
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-60306
record_format dspace
spelling th-cmuir.6653943832-603062018-09-10T03:40:51Z Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis Sakornrat Khongkhunthian Napachakorn Srimueang Suttichai Krisanaprakornkit Komkham Pattanaporn Siriwan Ong-Chai Prachya Kongtawelert Dentistry Aim: To determine the levels of chondroitin sulphate (CS) WF6 epitope, recognized by WF6 monoclonal antibody, in gingival crevicular fluid (GCF) from different stages of periodontal disease and healthy periodontium, and to correlate those levels with clinical parameters. Material and Methods: GCF samples, collected from 389 sites, were analysed for the WF6 epitope levels by the competitive enzyme-linked immunosorbent assay. Results: The median WF6 epitope level was significantly higher in chronic periodontitis sites (n=185) than in healthy and gingivitis sites (n=204) (p<0.001), whereas the median levels did not significantly differ between healthy (n=65) and gingivitis sites (n=139). The median level in severe periodontitis sites (n=60) was significantly higher than that in moderate periodontitis sites (n=63) (p=0.019). Similarly, the median level in moderate periodontitis sites was significantly higher than that in slight periodontitis sites (n=62) (p=0.001). The WF6 epitope levels significantly correlated with probing depth (r=0.777, p=0.001) and loss of clinical attachment level (r=0.814, p=0.001). Conclusion: Elevated CS WF6 epitope levels in GCF are associated with severity of periodontitis. The WF6 antibody may therefore be clinically applied to monitor disease severity and progression. © 2008 Blackwell Munksgaard. 2018-09-10T03:40:51Z 2018-09-10T03:40:51Z 2008-10-01 Journal 1600051X 03036979 2-s2.0-51749107033 10.1111/j.1600-051X.2008.01312.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=51749107033&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60306
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Dentistry
spellingShingle Dentistry
Sakornrat Khongkhunthian
Napachakorn Srimueang
Suttichai Krisanaprakornkit
Komkham Pattanaporn
Siriwan Ong-Chai
Prachya Kongtawelert
Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
description Aim: To determine the levels of chondroitin sulphate (CS) WF6 epitope, recognized by WF6 monoclonal antibody, in gingival crevicular fluid (GCF) from different stages of periodontal disease and healthy periodontium, and to correlate those levels with clinical parameters. Material and Methods: GCF samples, collected from 389 sites, were analysed for the WF6 epitope levels by the competitive enzyme-linked immunosorbent assay. Results: The median WF6 epitope level was significantly higher in chronic periodontitis sites (n=185) than in healthy and gingivitis sites (n=204) (p<0.001), whereas the median levels did not significantly differ between healthy (n=65) and gingivitis sites (n=139). The median level in severe periodontitis sites (n=60) was significantly higher than that in moderate periodontitis sites (n=63) (p=0.019). Similarly, the median level in moderate periodontitis sites was significantly higher than that in slight periodontitis sites (n=62) (p=0.001). The WF6 epitope levels significantly correlated with probing depth (r=0.777, p=0.001) and loss of clinical attachment level (r=0.814, p=0.001). Conclusion: Elevated CS WF6 epitope levels in GCF are associated with severity of periodontitis. The WF6 antibody may therefore be clinically applied to monitor disease severity and progression. © 2008 Blackwell Munksgaard.
format Journal
author Sakornrat Khongkhunthian
Napachakorn Srimueang
Suttichai Krisanaprakornkit
Komkham Pattanaporn
Siriwan Ong-Chai
Prachya Kongtawelert
author_facet Sakornrat Khongkhunthian
Napachakorn Srimueang
Suttichai Krisanaprakornkit
Komkham Pattanaporn
Siriwan Ong-Chai
Prachya Kongtawelert
author_sort Sakornrat Khongkhunthian
title Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
title_short Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
title_full Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
title_fullStr Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
title_full_unstemmed Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis
title_sort raised chondroitin sulphate wf6 epitope levels in gingival crevicular fluid in chronic periodontitis
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=51749107033&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60306
_version_ 1681425411475505152